{"id":"alka-seltzer-extra-strength","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Allergic reactions (in aspirin-sensitive individuals)"},{"rate":null,"effect":"Renal effects with chronic use"}]},"_chembl":null,"_dailymed":{"setId":"4a16b6e5-f0c6-e3a4-e063-6294a90a85ad","title":"ALKA-SELTZER EXTRA STRENGTH PAIN RELIEF (ANHYDROUS CITRIC ACID, ASPIRIN) TABLET, EFFERVESCENT [BAYER HEALTHCARE LLC.]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"The sodium bicarbonate acts as an antacid to neutralize gastric acid and provide rapid relief of heartburn and indigestion. The aspirin provides analgesic and anti-inflammatory effects by inhibiting cyclooxygenase (COX) enzymes and reducing prostaglandin synthesis. The citric acid enhances the effervescent action and aids in rapid dissolution and absorption.","oneSentence":"Alka-Seltzer Extra Strength combines aspirin, citric acid, and sodium bicarbonate to neutralize stomach acid and provide analgesic and anti-inflammatory relief.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T05:52:25.259Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Heartburn and indigestion relief"},{"name":"Mild to moderate pain and fever"},{"name":"Acid reflux symptoms"}]},"trialDetails":[{"nctId":"NCT01209806","phase":"NA","title":"The Effects of Moviprep With Simethicone on Colonic Bubbles","status":"COMPLETED","sponsor":"Thomas Jefferson University","startDate":"2009-11","conditions":"Bubbles in Colon at Time of Colonoscopy","enrollment":140},{"nctId":"NCT01081353","phase":"PHASE1","title":"Pharmacokinetic Study Comparing Aspirin and Effervescent Aspirin","status":"COMPLETED","sponsor":"Bayer","startDate":"2010-02","conditions":"Pharmacokinetics","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Alka Seltzer Extra Strength","genericName":"Alka Seltzer Extra Strength","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Alka-Seltzer Extra Strength combines aspirin, citric acid, and sodium bicarbonate to neutralize stomach acid and provide analgesic and anti-inflammatory relief. Used for Heartburn and indigestion relief, Mild to moderate pain and fever, Acid reflux symptoms.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}