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Dexpanthenol (BAY81-2996)
Dexpanthenol is converted to pantothenic acid (vitamin B5), which serves as a precursor for coenzyme A, essential for cellular metabolism and tissue repair.
Dexpanthenol is converted to pantothenic acid (vitamin B5), which serves as a precursor for coenzyme A, essential for cellular metabolism and tissue repair. Used for Wound healing and tissue repair, Dermatitis and skin irritation, Post-operative wound care.
At a glance
| Generic name | Dexpanthenol (BAY81-2996) |
|---|---|
| Sponsor | Bayer |
| Drug class | Vitamin B5 analog / Tissue repair agent |
| Target | Pantothenic acid pathway / Coenzyme A synthesis |
| Modality | Small molecule |
| Therapeutic area | Dermatology / Wound Care |
| Phase | FDA-approved |
Mechanism of action
Dexpanthenol is the biologically active form of pantothenic acid that is rapidly converted to pantothenic acid in the body. Pantothenic acid is a B vitamin that functions as a precursor for coenzyme A (CoA), a critical cofactor in numerous metabolic pathways including energy production, fatty acid synthesis, and acetylcholine synthesis. This supports cellular regeneration, wound healing, and skin barrier function.
Approved indications
- Wound healing and tissue repair
- Dermatitis and skin irritation
- Post-operative wound care
- Minor burns and abrasions
Common side effects
- Local irritation at application site
- Allergic contact dermatitis
- Mild burning or stinging sensation
Key clinical trials
- Pilot Study to Assess Number of Patients for Main Trial (PHASE4)
- Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries (PHASE4)
- Comparative Safety Study of New Sinecort Formulation Versus Positive Control (PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Dexpanthenol (BAY81-2996) CI brief — competitive landscape report
- Dexpanthenol (BAY81-2996) updates RSS · CI watch RSS
- Bayer portfolio CI