{"id":"dexpanthenol-bay81-2996","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation at application site"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Mild burning or stinging sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexpanthenol is the biologically active form of pantothenic acid that is rapidly converted to pantothenic acid in the body. Pantothenic acid is a B vitamin that functions as a precursor for coenzyme A (CoA), a critical cofactor in numerous metabolic pathways including energy production, fatty acid synthesis, and acetylcholine synthesis. This supports cellular regeneration, wound healing, and skin barrier function.","oneSentence":"Dexpanthenol is converted to pantothenic acid (vitamin B5), which serves as a precursor for coenzyme A, essential for cellular metabolism and tissue repair.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:44:41.103Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Wound healing and tissue repair"},{"name":"Dermatitis and skin irritation"},{"name":"Post-operative wound care"},{"name":"Minor burns and abrasions"}]},"trialDetails":[{"nctId":"NCT02734628","phase":"PHASE4","title":"Pilot Study to Assess Number of Patients for Main Trial","status":"COMPLETED","sponsor":"Bayer","startDate":"2007-03","conditions":"Wound Healing","enrollment":28},{"nctId":"NCT00859196","phase":"PHASE4","title":"Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-02","conditions":"Wound Healing, Cell Proliferation, Gene Expression","enrollment":15},{"nctId":"NCT00885937","phase":"PHASE1","title":"Comparative Safety Study of New Sinecort Formulation Versus Positive Control","status":"COMPLETED","sponsor":"Bayer","startDate":"2009-04","conditions":"Healthy","enrollment":33}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Dexpanthenol (BAY81-2996)","genericName":"Dexpanthenol (BAY81-2996)","companyName":"Bayer","companyId":"bayer","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dexpanthenol is converted to pantothenic acid (vitamin B5), which serves as a precursor for coenzyme A, essential for cellular metabolism and tissue repair. Used for Wound healing and tissue repair, Dermatitis and skin irritation, Post-operative wound care.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}