Last reviewed 2026-05-15 · How we verify

Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin

Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin is a Beta-lactam antibiotics and macrolide antibiotics Small molecule drug developed by Bayer. It is currently in Phase 3 development for Bacterial infections susceptible to beta-lactams and macrolides (respiratory tract infections, otitis media, sinusitis, skin infections), Community-acquired pneumonia, Helicobacter pylori eradication (amoxicillin/clavulanate with clarithromycin).

This is a combination of four beta-lactam and macrolide antibiotics that work by inhibiting bacterial cell wall synthesis and protein synthesis to kill or inhibit growth of susceptible bacteria.

This is a combination of four beta-lactam and macrolide antibiotics that work by inhibiting bacterial cell wall synthesis and protein synthesis to kill or inhibit growth of susceptible bacteria. Used for Bacterial infections susceptible to beta-lactams and macrolides (respiratory tract infections, otitis media, sinusitis, skin infections), Community-acquired pneumonia, Helicobacter pylori eradication (amoxicillin/clavulanate with clarithromycin).

At a glance

Mechanism of action

Ceftriaxone, amoxicillin/clavulanate, and clarithromycin are bactericidal agents that inhibit bacterial peptidoglycan cross-linking in the cell wall. Azithromycin and clarithromycin are macrolides that inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. Clavulanate is a beta-lactamase inhibitor that protects amoxicillin from enzymatic degradation. Together, these agents provide broad-spectrum coverage against gram-positive and gram-negative bacteria.

Approved indications

• Bacterial infections susceptible to beta-lactams and macrolides (respiratory tract infections, otitis media, sinusitis, skin infections)
• Community-acquired pneumonia
• Helicobacter pylori eradication (amoxicillin/clavulanate with clarithromycin)

Common side effects

• Diarrhea
• Nausea
• Abdominal pain
• Rash
• Vomiting
• Allergic reaction
• QT prolongation (macrolides)

Key clinical trials

• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (PHASE3)
• Patients Response to Early Switch To Oral:Osteomyelitis Study (EARLY_PHASE1)
• A Study to Assess the Efficacy and Safety of IV/PO Moxifloxacin in Subjects With Community-acquired Pneumonia (PHASE3)

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Competitive intelligence

For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:

• Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin CI brief — competitive landscape report
• Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin updates RSS · CI watch RSS
• Bayer portfolio CI

Frequently asked questions about Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin

Related

• Drug class: All Beta-lactam antibiotics and macrolide antibiotics drugs
• Target: All drugs targeting Bacterial cell wall (penicillin-binding proteins) and bacterial ribosome (50S subunit)
• Manufacturer: Bayer — full pipeline
• Therapeutic area: All drugs in Infectious Disease
• Indication: Drugs for Bacterial infections susceptible to beta-lactams and macrolides (respiratory tract infections, otitis media, sinusitis, skin infections)
• Indication: Drugs for Community-acquired pneumonia
• Indication: Drugs for Helicobacter pylori eradication (amoxicillin/clavulanate with clarithromycin)
• Compare: Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin vs similar drugs
• Pricing: Ceftriaxone; Azithromycin; Amoxicilline/clavulanate; Clarithromycin cost, discount & access