What is Actidil used for?

Actidil is indicated for Cough relief, Minor aches and pains relief, Sore throat relief, Headache relief, Runny nose relief.

Actidil is developed by Novartis.

What development phase is Actidil in?

Actidil is FDA-approved (marketed).

What is the generic name of Actidil?

TRIPROLIDINE is the generic (nonproprietary) name of Actidil.

Last reviewed 2026-04-20 · How we verify

Actidil (TRIPROLIDINE)

Novartis · FDA-approved approved Small molecule Quality 35/100

Actidil (triprolidine) is a small molecule histamine H1 receptor antagonist developed by SANDOZ, targeting allergic conditions such as conjunctivitis, rhinitis, and urticaria. It was FDA approved in 1983 and is currently off-patent with multiple generic manufacturers. Actidil works by blocking the histamine H1 receptor, reducing symptoms associated with allergic reactions. The commercial status of Actidil is generic, with no active Orange Book patents. Key safety considerations include its low bioavailability of 4%.

At a glance

Generic name	TRIPROLIDINE
Sponsor	Novartis
Drug class	triprolidine
Target	Histamine H1 receptor
Modality	Small molecule
Therapeutic area	Infectious Disease
Phase	FDA-approved
First approval	1983

Approved indications

Cough relief
Minor aches and pains relief
Sore throat relief
Headache relief
Runny nose relief
Sneezing relief
Nasal/throat itching relief
Eye itching relief
Fever reduction
Cough control for sleep

Common side effects

No common side effects on file.

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

Source	Used for
FDA label	Mechanism, indications, dosing, boxed warnings, drug interactions