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The midazolam group
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, producing sedation, anxiolysis, and muscle relaxation.
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at the GABA-A receptor, producing sedation, anxiolysis, and muscle relaxation. Used for Sedation and anxiolysis in clinical procedures, Induction of general anesthesia, Acute anxiety and agitation management.
At a glance
| Generic name | The midazolam group |
|---|---|
| Sponsor | Kasr El Aini Hospital |
| Drug class | Benzodiazepine |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia, Sedation, Anxiety |
| Phase | Phase 3 |
Mechanism of action
Midazolam binds to allosteric sites on GABA-A receptors in the central nervous system, increasing the frequency of chloride channel opening and hyperpolarizing neuronal membranes. This potentiation of GABAergic inhibition results in dose-dependent depression of the central nervous system, making it useful for sedation, anxiolysis, and anesthesia induction. The drug has a rapid onset and short duration of action due to its high lipophilicity and rapid redistribution.
Approved indications
- Sedation and anxiolysis in clinical procedures
- Induction of general anesthesia
- Acute anxiety and agitation management
Common side effects
- Respiratory depression
- Hypotension
- Oversedation
- Amnesia
- Headache
- Dizziness
Key clinical trials
- SMILE Trial - Imaging Sub-Study
- Comparison of Two Intravenous Drug Combinations for Ambulatory Oral & Maxillofacial Surgery (PHASE1)
- Management of Catatonic Features in Adolescents With Profound Autism (NA)
- HIFU Versus Myomectomy for the Treatment of Symptomatic Uterine Fibroids (NA)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (PHASE3)
- The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia (NA)
- A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) (PHASE1, PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |