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C=Inhaled Alprazolam 1 m

Alexza Pharmaceuticals, Inc. · Phase 2 active Small molecule

Alprazolam acts as a positive allosteric modulator of the GABAA receptor, enhancing the inhibitory effects of GABA in the central nervous system.

Alprazolam acts as a positive allosteric modulator of the GABAA receptor, enhancing the inhibitory effects of GABA in the central nervous system. Used for Anxiety disorders, Panic disorders.

At a glance

Generic nameC=Inhaled Alprazolam 1 m
SponsorAlexza Pharmaceuticals, Inc.
Drug classbenzodiazepine
TargetGABAA receptor
ModalitySmall molecule
Therapeutic areaNeurology
PhasePhase 2

Mechanism of action

By binding to specific sites on the GABAA receptor, alprazolam potentiates the action of GABA, leading to increased chloride ion influx and hyperpolarization of neurons, which results in sedative, anxiolytic, and anticonvulsant effects.

Approved indications

Common side effects

Key clinical trials

Primary sources

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SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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