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midazolam intravenous administration
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation, anxiolysis, and amnesia.
Midazolam is a benzodiazepine that enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, producing sedation, anxiolysis, and amnesia. Used for Procedural sedation and anxiolysis, Induction of general anesthesia, Acute seizure management.
At a glance
| Generic name | midazolam intravenous administration |
|---|---|
| Also known as | hypnovel |
| Sponsor | University Hospital, Lille |
| Drug class | Benzodiazepine |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Sedation |
| Phase | FDA-approved |
Mechanism of action
Midazolam binds to GABA-A receptors and potentiates the effect of the inhibitory neurotransmitter GABA, leading to increased chloride ion influx and neuronal hyperpolarization. This results in depression of the central nervous system with sedative, anxiolytic, anticonvulsant, and muscle relaxant properties. When administered intravenously, it has rapid onset and short duration of action, making it suitable for procedural sedation and anesthesia induction.
Approved indications
- Procedural sedation and anxiolysis
- Induction of general anesthesia
- Acute seizure management
- Preoperative anxiolysis
Common side effects
- Respiratory depression
- Hypotension
- Oversedation
- Headache
- Nausea
- Amnesia
Key clinical trials
- Effects of TAP and QLB-1 Blocks on Opioid Consumption (NA)
- A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100) (PHASE1, PHASE2)
- Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy (NA)
- Propofol vs Remifentanil for Sedation in Gastroscopy (NA)
- Phase III Trial of Anlotinib, Catequentinib in Advanced Alveolar Soft Part Sarcoma, Leiomyosarcoma, Synovial Sarcoma (APROMISS) (PHASE3)
- A Study to Assess the Time to Onset of Action of Staccato Alprazolam Versus Midazolam and Diazepam in Healthy Participants (PHASE1)
- The Role of Coadministration of Lidocaine and Ketamine in Opioid-Refractory Chronic Cancer-Related Pain. (EARLY_PHASE1)
- Supraclavicular Block vs Bier's Block for Forearm Trauma Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- midazolam intravenous administration CI brief — competitive landscape report
- midazolam intravenous administration updates RSS · CI watch RSS
- University Hospital, Lille portfolio CI