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Remimazolam based total intravenous anesthesia
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anesthesia.
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anesthesia. Used for Induction and maintenance of general anesthesia in adults, Sedation during procedural anesthesia.
At a glance
| Generic name | Remimazolam based total intravenous anesthesia |
|---|---|
| Sponsor | The First Affiliated Hospital of Anhui Medical University |
| Drug class | Benzodiazepine |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Remimazolam potentiates the inhibitory effects of GABA at GABA-A receptors in the central nervous system, leading to sedation, anxiolysis, and anesthesia. As an ester-based benzodiazepine, it is rapidly metabolized by non-specific esterases, providing a shorter duration of action compared to traditional benzodiazepines. When used as part of total intravenous anesthesia (TIVA), it serves as the sedative-hypnotic component alongside opioids and other agents.
Approved indications
- Induction and maintenance of general anesthesia in adults
- Sedation during procedural anesthesia
Common side effects
- Hypotension
- Respiratory depression
- Bradycardia
- Injection site pain
Key clinical trials
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery (NA)
- Remiazolam vs Propofol Total Intravenous Anesthesia on Postoperative Neurodevelopment After General Anesthesia in Children (PHASE4)
- Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position (PHASE4)
- Remimazolam Versus Propopol Based Total Intravenous Anesthesia for Breast Surgery (NA)
- Comparison of Quality of Recovery Between Remimazolam and Propofol Anesthesia in Patients Undergoing Arthroscopic Meniscectomy (NA)
- Anesthesia and Non-small Cell Lung Cancer Recurrence (PHASE4)
- Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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