{"id":"remimazolam-based-total-intravenous-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Injection site pain"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Remimazolam potentiates the inhibitory effects of GABA at GABA-A receptors in the central nervous system, leading to sedation, anxiolysis, and anesthesia. As an ester-based benzodiazepine, it is rapidly metabolized by non-specific esterases, providing a shorter duration of action compared to traditional benzodiazepines. When used as part of total intravenous anesthesia (TIVA), it serves as the sedative-hypnotic component alongside opioids and other agents.","oneSentence":"Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:37:12.901Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Induction and maintenance of general anesthesia in adults"},{"name":"Sedation during procedural anesthesia"}]},"trialDetails":[{"nctId":"NCT07251101","phase":"NA","title":"Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery","status":"NOT_YET_RECRUITING","sponsor":"Ilsan Cha hospital","startDate":"2026-05-02","conditions":"Anesthesia, Intravenous, Hemodynamic Stability, Gynecologic Surgery","enrollment":58},{"nctId":"NCT07265050","phase":"NA","title":"Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery","status":"NOT_YET_RECRUITING","sponsor":"Seoul National University Hospital","startDate":"2026-01-01","conditions":"Emergence Agitation","enrollment":204},{"nctId":"NCT07194109","phase":"PHASE4","title":"Remiazolam vs Propofol Total Intravenous Anesthesia on Postoperative Neurodevelopment After General Anesthesia in Children","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Anhui Medical University","startDate":"2025-10-01","conditions":"Adenotonsillar Hypertrophy","enrollment":558},{"nctId":"NCT05644483","phase":"PHASE4","title":"Effect of Remimazolam and Propofol on Hemodynamic Stability in Prone Position","status":"COMPLETED","sponsor":"Asan Medical Center","startDate":"2022-03-29","conditions":"Hemodynamic Instability","enrollment":94},{"nctId":"NCT05375747","phase":"NA","title":"Remimazolam Versus Propopol Based Total Intravenous Anesthesia for Breast Surgery","status":"WITHDRAWN","sponsor":"Seoul National University Hospital","startDate":"2022-06-13","conditions":"Hypotension","enrollment":""},{"nctId":"NCT05280236","phase":"NA","title":"Comparison of Quality of Recovery Between Remimazolam and Propofol Anesthesia in Patients Undergoing Arthroscopic Meniscectomy","status":"COMPLETED","sponsor":"Yonsei University","startDate":"2022-03-14","conditions":"Adult Patients 19 or Older Scheduled for Elective Arthroscopic Meniscectomy","enrollment":80},{"nctId":"NCT06330038","phase":"PHASE4","title":"Anesthesia and Non-small Cell Lung Cancer Recurrence","status":"NOT_YET_RECRUITING","sponsor":"Samsung Medical Center","startDate":"2024-05-01","conditions":"Non-small Cell Lung Cancer, Surgery, Anesthesia","enrollment":5384},{"nctId":"NCT04994704","phase":"NA","title":"Comparison of Postoperative QoR-15 Scores Between Propofol and Remimazolam","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2021-12-01","conditions":"Patients Undergoing Spine Surgery","enrollment":73},{"nctId":"NCT05047939","phase":"NA","title":"Comparison of Recovery Profile After TIVA Between Remimazolam With Flumazenil and Propofol","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2021-12-14","conditions":"Anesthesia, Intravenous","enrollment":58},{"nctId":"NCT05019222","phase":"NA","title":"Comparison of Postoperative QoR-15 Scores Between Sevoflurane and Remimazolam","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2021-09-26","conditions":"Anterior Cervical Discectomy and Fusion (ACDF) Surgery","enrollment":72},{"nctId":"NCT05435911","phase":"NA","title":"Comparison of Recovery From General Anesthesia in Remimazolam With Flumazenil vs. Propofol","status":"COMPLETED","sponsor":"Seoul National University Hospital","startDate":"2022-08-02","conditions":"Recovery","enrollment":66},{"nctId":"NCT05615441","phase":"NA","title":"Effect of Nociception Level Monitoring During Remimazolam-based Total Intravenous Anesthesia on Intraoperative Opioid Requirements and Postoperative Pain","status":"UNKNOWN","sponsor":"Yonsei University","startDate":"2022-11-02","conditions":"Adult Patients Aged 19-64, Scheduled for Elective Arthroscopic Knee Surgery","enrollment":58},{"nctId":"NCT05016518","phase":"NA","title":"Comparison of Quality of Recovery (QoR)-15 Scores Between Propofol and Remimazolam Anesthesia","status":"COMPLETED","sponsor":"Gangnam Severance Hospital","startDate":"2021-09-16","conditions":"Patients Undergoing Thyroid Surgery for Neoplasm","enrollment":140},{"nctId":"NCT03669484","phase":"PHASE3","title":"Comparative Clinical Study of Efficacy and Safety of Remimazolam and Propofol in Patients Undergoing Elective Surgery Under General Anaesthesia","status":"COMPLETED","sponsor":"R-Pharm","startDate":"2017-08-22","conditions":"General Anaesthesia","enrollment":150}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Remimazolam based total intravenous anesthesia","genericName":"Remimazolam based total intravenous anesthesia","companyName":"The First Affiliated Hospital of Anhui Medical University","companyId":"the-first-affiliated-hospital-of-anhui-medical-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing sedation and anesthesia. Used for Induction and maintenance of general anesthesia in adults, Sedation during procedural anesthesia.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}