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Diazepam Injectable Solution
Diazepam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability.
Diazepam enhances the inhibitory effects of GABA at GABA-A receptors in the central nervous system, reducing neuronal excitability. Used for Acute seizures and status epilepticus, Acute anxiety and agitation, Muscle spasms and spasticity.
At a glance
| Generic name | Diazepam Injectable Solution |
|---|---|
| Sponsor | Centro Medico Nacional La Raza, IMSS |
| Drug class | Benzodiazepine |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Neurology, Psychiatry, Critical Care |
| Phase | FDA-approved |
Mechanism of action
Diazepam is a benzodiazepine that binds allosterically to GABA-A receptors, potentiating the effect of the inhibitory neurotransmitter GABA. This results in increased chloride ion influx into neurons, leading to hyperpolarization and reduced firing. The injectable formulation provides rapid onset for acute management of seizures, muscle spasms, and anxiety.
Approved indications
- Acute seizures and status epilepticus
- Acute anxiety and agitation
- Muscle spasms and spasticity
- Alcohol withdrawal syndrome
- Preoperative sedation
Common side effects
- Drowsiness and sedation
- Dizziness and ataxia
- Respiratory depression
- Hypotension
- Dependence and withdrawal
- Injection site reactions
Key clinical trials
- Prospective Opioid-Free AIS Fusion (PHASE4)
- Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability (PHASE4)
- Association Between Bolus Rate and the Adequacy of Labor Analgesia Using Timed-intermittent Boluses (NA)
- A Study of Diazepam After Intranasal and Intravenous Administration to Healthy Volunteers (PHASE1)
- Treatment Of Alcohol Withdrawal Syndrome: Dexmedetomidine Vs Diazepam In A Hospital O'horán (PHASE4)
- Efficacy and Safety of Diazepam in the Management of Refractory Epilepsy in Selected Patients Who Require Intermittent Medical Intervention for Acute Repetitive Seizures. (PHASE3)
- The Comparison of Different Administration Routes of Pediatric Premedication (PHASE4)
- Diazepam at the Active Phase of Labor (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Diazepam Injectable Solution CI brief — competitive landscape report
- Diazepam Injectable Solution updates RSS · CI watch RSS
- Centro Medico Nacional La Raza, IMSS portfolio CI