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Anesthesia induction with remimazolam
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing rapid sedation and anesthesia induction.
Remimazolam is a benzodiazepine that enhances GABAergic neurotransmission by binding to GABA-A receptors, producing rapid sedation and anesthesia induction. Used for Induction of general anesthesia in adults.
At a glance
| Generic name | Anesthesia induction with remimazolam |
|---|---|
| Sponsor | Daegu Catholic University Medical Center |
| Drug class | Benzodiazepine |
| Target | GABA-A receptor |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Remimazolam is an ultra-short-acting benzodiazepine ester prodrug that is rapidly metabolized by non-specific esterases in the blood and tissues, allowing for quick onset and offset of action. It binds allosterically to GABA-A receptors in the central nervous system, potentiating inhibitory GABAergic signaling to produce sedation, anxiolysis, and anesthesia. Its ester structure and rapid metabolism distinguish it from longer-acting benzodiazepines, making it suitable for induction of general anesthesia.
Approved indications
- Induction of general anesthesia in adults
Common side effects
- Hypotension
- Respiratory depression
- Injection site pain
- Headache
Key clinical trials
- Hemodynamic Effects of Remimazolam vs Propofol During Robot-assisted Gynecologic Surgery (NA)
- Correlating EEG Dynamics With Consciousness Alteration Under Anesthesia
- ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients (NA)
- Characteristic Electroencephalogram of General Anesthesia
- Effect of Remimazolam on Postoperative Delirium (NA)
- A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined With Alfentanil for Anesthesia in Thoracic Surgery (PHASE4)
- Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery (PHASE4)
- Comparison of Emergence Agitation Between Remimazolam With Flumazenil and Propofol-based Total Intravenous Anesthesia in Patients Undergoing Nasal Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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