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Carboplatin-Taxol-Radiotherapy
Carboplatin-Taxol-Radiotherapy is a Platinum-based chemotherapy, Microtubule inhibitor, Radiation therapy Small molecule drug developed by Hospices Civils de Lyon. It is currently in Phase 2 development for Advanced ovarian cancer, Small cell lung cancer.
Carboplatin is a platinum-based chemotherapy drug that interferes with DNA replication, while Taxol (paclitaxel) is a microtubule inhibitor that prevents cell division. Radiotherapy uses ionizing radiation to kill cancer cells.
Carboplatin is a platinum-based chemotherapy drug that interferes with DNA replication, while Taxol (paclitaxel) is a microtubule inhibitor that prevents cell division. Radiotherapy uses ionizing radiation to kill cancer cells. Used for Advanced ovarian cancer, Small cell lung cancer.
At a glance
| Generic name | Carboplatin-Taxol-Radiotherapy |
|---|---|
| Sponsor | Hospices Civils de Lyon |
| Drug class | Platinum-based chemotherapy, Microtubule inhibitor, Radiation therapy |
| Modality | Small molecule |
| Therapeutic area | Oncology |
| Phase | Phase 2 |
Mechanism of action
Carboplatin works by forming platinum-DNA adducts, which prevent DNA replication and transcription. Taxol, on the other hand, stabilizes microtubules, preventing their disassembly and thereby blocking cell division. Radiotherapy induces DNA damage and apoptosis in cancer cells.
Approved indications
- Advanced ovarian cancer
- Small cell lung cancer
Common side effects
- Myelosuppression
- Neutropenia
- Nausea and vomiting
- Diarrhea
- Fatigue
Key clinical trials
- A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032) (PHASE3)
- Testing the Addition of Chemotherapy or Chemo-Immunotherapy to the Usual Surgery for Advanced Head and Neck Cancer (PHASE2)
- Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery (PHASE1, PHASE2)
- Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery (PHASE2, PHASE3)
- Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer (PHASE3)
- Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients With Unresectable Stage III Non-Small Cell Lung Cancer (PHASE3)
- Testing the Safety and Efficacy of the Addition of a New Anti-cancer Drug, ZEN003694, to Chemotherapy Treatment (Cisplatin and Etoposide or Carboplatin and Paclitaxel) for Adult and Pediatric Patients (12-17 Years) With NUT Carcinoma (PHASE1, PHASE2)
- Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Carboplatin-Taxol-Radiotherapy CI brief — competitive landscape report
- Carboplatin-Taxol-Radiotherapy updates RSS · CI watch RSS
- Hospices Civils de Lyon portfolio CI
Frequently asked questions about Carboplatin-Taxol-Radiotherapy
What is Carboplatin-Taxol-Radiotherapy?
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Who makes Carboplatin-Taxol-Radiotherapy?
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Related
- Drug class: All Platinum-based chemotherapy, Microtubule inhibitor, Radiation therapy drugs
- Manufacturer: Hospices Civils de Lyon — full pipeline
- Therapeutic area: All drugs in Oncology
- Indication: Drugs for Advanced ovarian cancer
- Indication: Drugs for Small cell lung cancer
- Compare: Carboplatin-Taxol-Radiotherapy vs similar drugs
- Pricing: Carboplatin-Taxol-Radiotherapy cost, discount & access