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Naropin, 0.5% Injectable Solution
Naropin is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses.
Naropin is a local anesthetic that works by blocking sodium channels in nerve fibers, preventing the initiation and transmission of nerve impulses. Used for Local or regional anesthesia for surgical procedures, epidural anesthesia for pain relief during labor, and infiltration anesthesia for minor surgical procedures.
At a glance
| Generic name | Naropin, 0.5% Injectable Solution |
|---|---|
| Also known as | ropivacaine HCl |
| Sponsor | Cali Pharmaceuticals LLC |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
This action results in a temporary loss of sensation in the area where Naropin is administered, providing pain relief. Naropin is a lidocaine derivative, which is a well-established class of local anesthetics.
Approved indications
- Local or regional anesthesia for surgical procedures, epidural anesthesia for pain relief during labor, and infiltration anesthesia for minor surgical procedures
Common side effects
- Nervous system effects (e.g. dizziness, tinnitus, seizures)
- Cardiovascular effects (e.g. hypotension, bradycardia)
- Respiratory effects (e.g. respiratory depression)
Key clinical trials
- A Clinical Trial Evaluating the Efficacy, Safety, and Pharmacokinetic Profile of TRD303 for Postoperative Analgesia After Abdominal Surgery in China. (PHASE3)
- CPL-01 in the Management of Postoperative Pain After Bunionectomy (PHASE3)
- Zynrelef Versus Adductor Canal Block (PHASE4)
- PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty (PHASE4)
- Intrathecal MoRphine Versus Transabdominal Plane Block (TAP) Block for AnalGesic Management in Elective Caesarean Section (PHASE4)
- Liposomal Bupivacaine vs Continuous Nerve Catheters for Below the Knee Amputations (PHASE4)
- Post Operative Infusion Pump Pain Study (PHASE4)
- The Impact of Local Anesthetic Dilution on Possible Blinding for Nerve Blocks (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |