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Topical liquid lidocaine
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Oral mucositis pain relief in cancer patients, Localized pain management in cancer care settings.
At a glance
| Generic name | Topical liquid lidocaine |
|---|---|
| Sponsor | OHSU Knight Cancer Institute |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Oncology (supportive care) |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby blocking the generation and propagation of action potentials. When applied topically, it numbs the skin and mucous membranes in the area of application. This mechanism makes it useful for reducing pain and discomfort in localized areas, particularly in cancer patients experiencing oral mucositis or other localized pain conditions.
Approved indications
- Oral mucositis pain relief in cancer patients
- Localized pain management in cancer care settings
Common side effects
- Local irritation or burning at application site
- Allergic contact dermatitis
- Systemic toxicity (if absorbed in large amounts)
Key clinical trials
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Intrauterine Device Insertion Pain Management (PHASE4)
- Virtual Reality During Lumbar Punctures in Acute Lymphoblastic Leukemia (NA)
- Topical Anaesthesia in Cutaneous Head and Neck Surgery (NA)
- Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis (PHASE4)
- An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sampling Techniques (NA)
- An Exploratory Study in Healthy Volunteers to Identify Factors Influencing Bioequivalence Studies on Moderately Lipophilic Drugs Using Dermal Open Flow Microperfusion (dOFM) (NA)
- Screening for Colorectal Cancer in Average and High Risk Population (EARLY_PHASE1)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical liquid lidocaine CI brief — competitive landscape report
- Topical liquid lidocaine updates RSS · CI watch RSS
- OHSU Knight Cancer Institute portfolio CI