{"id":"topical-liquid-lidocaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local irritation or burning at application site"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Systemic toxicity (if absorbed in large amounts)"}]},"_chembl":null,"_dailymed":{"setId":"2d97e75c-7dfd-417e-b8f3-31e8b5dd90fe","title":"LIDOSTREAM (LIDOCAINE 5% OINTMENT AND MENTHOL 10% TOPICAL LIQUID) KIT [UPSTREAM PHARMA, LLC]"},"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby blocking the generation and propagation of action potentials. When applied topically, it numbs the skin and mucous membranes in the area of application. This mechanism makes it useful for reducing pain and discomfort in localized areas, particularly in cancer patients experiencing oral mucositis or other localized pain conditions.","oneSentence":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:39:20.370Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Oral mucositis pain relief in cancer patients"},{"name":"Localized pain management in cancer care settings"}]},"trialDetails":[{"nctId":"NCT02870738","phase":"PHASE2","title":"Bladder Directed vs. Pelvic Floor Therapy in IC/BPS","status":"ACTIVE_NOT_RECRUITING","sponsor":"Corewell Health East","startDate":"2017-04-21","conditions":"Cystitis, Interstitial, Painful Bladder Syndrome","enrollment":128},{"nctId":"NCT06951191","phase":"PHASE4","title":"Intrauterine Device Insertion Pain 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Population","status":"COMPLETED","sponsor":"Lewai Sharki Abdulaziz, MSc PhD","startDate":"2015-04-01","conditions":"Colorectal Neoplasms, Colorectal Cancer, Adenomatous Polyp of Colon","enrollment":537},{"nctId":"NCT01898728","phase":"NA","title":"Comparison of the Effectiveness of Povidone-iodine in Reducing Conjunctival Bacterial Load Prior to Cataract Surgery in Patients Treated With a Lidocaine Gel Dilating Formulation Versus Eye Drops: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"McMaster University","startDate":"2012-12","conditions":"Cataracts","enrollment":101},{"nctId":"NCT01539317","phase":"PHASE3","title":"Therapy to Prevent Sexual Pain in Breast Cancer Survivors","status":"COMPLETED","sponsor":"OHSU Knight Cancer Institute","startDate":"2011-12","conditions":"Vulvodynia, Dyspareunia, Breast Cancer","enrollment":50},{"nctId":"NCT01503060","phase":"PHASE3","title":"Effectiveness of Parent-Led Interventions in Reducing Infant Hypersensitivity to Pain","status":"UNKNOWN","sponsor":"The Hospital for Sick Children","startDate":"2011-12","conditions":"Pain","enrollment":352},{"nctId":"NCT02015195","phase":"NA","title":"Effective Treatments for Jellyfish Stings","status":"COMPLETED","sponsor":"Stanford University","startDate":"2013-06","conditions":"Jellyfish Stings","enrollment":97},{"nctId":"NCT01087489","phase":"NA","title":"Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye","status":"COMPLETED","sponsor":"Miami VA Healthcare System","startDate":"2010-04","conditions":"Pain","enrollment":53}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Topical liquid lidocaine","genericName":"Topical liquid lidocaine","companyName":"OHSU Knight Cancer Institute","companyId":"ohsu-knight-cancer-institute","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Oral mucositis pain relief in cancer patients, Localized pain management in cancer care settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}