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Topical Lidocaine
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Topical anesthesia for minor cuts, wounds, and abrasions, Relief of pain and itching from minor skin irritations, Temporary numbing of skin prior to minor procedures.
At a glance
| Generic name | Topical Lidocaine |
|---|---|
| Also known as | Topical anesthetic, Topical, Versatis 5% Medicated Plaster, PL21727/0016., lidocaine gel, numbing gel, LMX-4 |
| Sponsor | Aultman Health Foundation |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain management / Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby blocking the generation and propagation of action potentials. When applied topically, it anesthetizes the area of application by preventing sensory nerve signals from reaching the central nervous system. This results in temporary loss of sensation in the treated region without affecting consciousness or motor function.
Approved indications
- Topical anesthesia for minor cuts, wounds, and abrasions
- Relief of pain and itching from minor skin irritations
- Temporary numbing of skin prior to minor procedures
Common side effects
- Local skin irritation or redness
- Allergic contact dermatitis
- Burning or stinging at application site
- Systemic toxicity (rare with topical use)
Key clinical trials
- The Analgesic Efficacy and Safety of Venlafaxine for Prevention of Postherpetic Neuralgia in Patients With Acute Herpes Zoster (NA)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Pain Experience Using Lidocaine Adrenaline Tetracaine (LAT) Gel Versus Lidocaine Infiltration for Laceration Repair in Adults (PHASE4)
- This Clinical Trial Aims to Compare the Effectiveness of Two Intra-pulpal Cryotherapy Techniques-Endo-ice and Ice Sticks-in Decreasing Intra-operative Pain and Enhancing the Success of Local Anesthesia During Pulpectomy of Mandibular Molars With Symptomatic Irreversible Pulpitis. (NA)
- Virtual Reality for Port-a-Cath Access (NA)
- EMLA Topical Cream for Treatment of Pain in Patients Receiving Intra-Dermal Technetium 99 Injections for Lymphoscintigraphy for Skin Cancers (PHASE2)
- Efficacy and Safety of TargetCool + Benev Exosomes in Patients With Hair Thinning (NA)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Topical Lidocaine CI brief — competitive landscape report
- Topical Lidocaine updates RSS · CI watch RSS
- Aultman Health Foundation portfolio CI