Topical Lidocaine — Competitive Intelligence Brief

Topical Lidocaine (Topical Lidocaine) competitive landscape: 6 comparators, recent regulatory actions, upcoming PDUFA, patent timeline. Class: Local anesthetic. Area: Pain management / Anesthesia.

marketed Local anesthetic Voltage-gated sodium channels Pain management / Anesthesia Small molecule

Target snapshot

Topical Lidocaine (Topical Lidocaine) — Aultman Health Foundation. Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.

Comparator set (6 drugs)

Drug	Generic	Sponsor	Phase	Class	Target	Approval / PDUFA
Topical Lidocaine TARGET	Topical Lidocaine	Aultman Health Foundation	marketed	Local anesthetic	Voltage-gated sodium channels
Standard dose lamotrigine	Standard dose lamotrigine	Mario Negri Institute for Pharmacological Research	marketed	Anticonvulsant / Antiepileptic drug	Voltage-gated sodium channels; glutamate release inhibition
Levobupivacaine plus sufentanil epidural infusion	Levobupivacaine plus sufentanil epidural infusion	University of Genova	marketed	Local anesthetic + opioid combination	Voltage-gated sodium channels (levobupivacaine); mu-opioid receptor (sufentanil)
Lidocaine + Esmolol (Combo)	Lidocaine + Esmolol (Combo)	Cedars-Sinai Medical Center	marketed	Local anesthetic + Beta-1 selective adrenergic antagonist	Voltage-gated sodium channels (lidocaine); Beta-1 adrenergic receptor (esmolol)
Articaine hydrochloride 2% solution	Articaine hydrochloride 2% solution	Helsinki University Central Hospital	marketed	Local anesthetic (amide type)	Voltage-gated sodium channels
Systemic Dexamethasone plus perineural bupivacaine	Systemic Dexamethasone plus perineural bupivacaine	Sherif Mohamed Abd el moneim Soaida, MD	marketed	Combination therapy: corticosteroid + local anesthetic	Glucocorticoid receptor (dexamethasone); voltage-gated sodium channels (bupivacaine)
Bupivacaine liposome	Bupivacaine liposome	Tianjin Medical University General Hospital	marketed	Local anesthetic (liposomal formulation)	Voltage-gated sodium channels

Recent regulatory actions (last 90 days)

No regulatory actions in the last 90 days for this set.

Upcoming PDUFA dates (next 180 days)

No PDUFA dates in the next 180 days for this set.

Patent timeline (forward window)

No upcoming patent expiries for this set.

Sponsor landscape (Local anesthetic class)

1. University of California, San Diego · 3 drugs in this class
2. Durect · 3 drugs in this class
3. Pacira Pharmaceuticals, Inc · 3 drugs in this class
4. Wake Forest University Health Sciences · 3 drugs in this class
5. Medical University of Vienna · 3 drugs in this class
6. Imperial College London · 2 drugs in this class
7. Hvidovre University Hospital · 2 drugs in this class
8. Innocoll · 2 drugs in this class
9. George Washington University · 2 drugs in this class
10. Guy's and St Thomas' NHS Foundation Trust · 2 drugs in this class