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Articaine hydrochloride 2% solution
Articaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Articaine hydrochloride is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local and regional anesthesia for dental procedures, Infiltration anesthesia, Nerve block anesthesia.
At a glance
| Generic name | Articaine hydrochloride 2% solution |
|---|---|
| Also known as | Ultracain D ohne Adrenalin 20 mg/ml, ATC code N01BB08 |
| Sponsor | Helsinki University Central Hospital |
| Drug class | Local anesthetic (amide type) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Articaine is an amide-type local anesthetic that reversibly inhibits sodium influx into nerve fibers, thereby preventing depolarization and action potential generation. This results in loss of sensation in the infiltrated tissue. Articaine is metabolized by plasma esterases and hepatic enzymes, with a relatively rapid onset and intermediate duration of action compared to other local anesthetics.
Approved indications
- Local and regional anesthesia for dental procedures
- Infiltration anesthesia
- Nerve block anesthesia
Common side effects
- Paresthesia
- Transient facial nerve paralysis
- Allergic reactions
- Systemic toxicity (at high doses)
Key clinical trials
- Radiographic and Histological Assessment of GBR Using DBB Compared to Spontaneous Bone Regeneration of Maxillary Defects , Resulted From Enucleation of Intra-bony Cystic Lesions (NA)
- Management of Excess Gingival Display Using Tunnel Technique With 3D Designed PEEK Shell: A Case Series (NA)
- 'Propolis Versus Chlorhexidine Gluconate on Wound Healing After Third Molar Surgery: a Randomized Controlled Trial' (NA)
- Digital vs. Conventional Anesthesia for Primary Tooth Extractions in Pediatric Patients (NA)
- On Previously Root Canal-treated Patients Using an AI Program, Detect the Accuracy of it in the Detection of Root Canal Obturation Quality on CBCT Compared With Conventional PA Radiography, e.g., Voids, Length of Obturation, and Density, and Then do Retreatment if Any Failure is Recorded. (NA)
- Anxiety and Hemodynamic Changes in Third Molar Extraction After Patient Education (NA)
- Effectiveness of the Comfort-In Needle Free Injection System During Palatal Infiltrative Anesthesia (NA)
- Combination of Buffered Anesthetic to Treat Mandibular Molars (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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