Last reviewed · How we verify
Levobupivacaine plus sufentanil epidural infusion
Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation, delivered together via epidural infusion for pain management.
Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation, delivered together via epidural infusion for pain management. Used for Epidural analgesia for postoperative pain management, Labor pain management, Chronic pain management via epidural infusion.
At a glance
| Generic name | Levobupivacaine plus sufentanil epidural infusion |
|---|---|
| Sponsor | University of Genova |
| Drug class | Local anesthetic + opioid combination |
| Target | Voltage-gated sodium channels (levobupivacaine); mu-opioid receptor (sufentanil) |
| Modality | Small molecule |
| Therapeutic area | Anesthesia and Pain Management |
| Phase | FDA-approved |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade. Sufentanil is a potent synthetic opioid that binds mu-opioid receptors in the central and peripheral nervous system to produce analgesia. The combination provides synergistic pain relief through dual mechanisms: local conduction blockade and systemic opioid analgesia.
Approved indications
- Epidural analgesia for postoperative pain management
- Labor pain management
- Chronic pain management via epidural infusion
Common side effects
- Hypotension
- Bradycardia
- Nausea and vomiting
- Pruritus
- Urinary retention
- Motor blockade
- Respiratory depression
Key clinical trials
- PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous (NA)
- Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG) (PHASE3)
- Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair (PHASE4)
- Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia (NA)
- Levobupivacaine for Epidural Analgesia in Labour (PHASE4)
- Comparative Affect of a Continuous Epidural Infusion of Clonidine During Labour. Prospective Double Blind Randomized Trial (PHASE3)
- Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape: