{"id":"levobupivacaine-plus-sufentanil-epidural-infusion","safety":{"commonSideEffects":[{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Urinary retention"},{"rate":null,"effect":"Motor blockade"},{"rate":null,"effect":"Respiratory depression"}]},"_chembl":{"chemblId":"CHEMBL1201193","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Levobupivacaine is the S-enantiomer of bupivacaine, a local anesthetic that reversibly inhibits sodium influx in nerve fibers, preventing action potential propagation and sensory/motor blockade. Sufentanil is a potent synthetic opioid that binds mu-opioid receptors in the central and peripheral nervous system to produce analgesia. The combination provides synergistic pain relief through dual mechanisms: local conduction blockade and systemic opioid analgesia.","oneSentence":"Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation, delivered together via epidural infusion for pain management.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:51:53.722Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Epidural analgesia for postoperative pain management"},{"name":"Labor pain management"},{"name":"Chronic pain management via epidural infusion"}]},"trialDetails":[{"nctId":"NCT01856166","phase":"NA","title":"PIEB-PCEA Versus CEI-PCEA for Labor Analgesia in Nulliparous","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2013-06","conditions":"Pregnancy","enrollment":304},{"nctId":"NCT02563821","phase":"PHASE3","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Third Trimester Medical Termination of Pregnancy Analgesia : a Randomized Study. (PCEA-IMG)","status":"COMPLETED","sponsor":"University Hospital, Limoges","startDate":"2015-11-05","conditions":"Anesthesia, Epidural","enrollment":37},{"nctId":"NCT02677532","phase":"PHASE4","title":"Epidural Versus Wound Infusion Plus Morphine Bolus in Open Abdominal Aortic Aneurysm Repair","status":"COMPLETED","sponsor":"University of Genova","startDate":"2011-12","conditions":"Postoperative Pain","enrollment":51},{"nctId":"NCT01860521","phase":"NA","title":"Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Termination of Pregnancy Analgesia","status":"COMPLETED","sponsor":"IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy","startDate":"2011-09","conditions":"Medical; Abortion, Fetus","enrollment":104},{"nctId":"NCT00929682","phase":"PHASE4","title":"Levobupivacaine for Epidural Analgesia in Labour","status":"COMPLETED","sponsor":"University Hospital, Clermont-Ferrand","startDate":"2007-06","conditions":"Analgesia, Epidural","enrollment":136},{"nctId":"NCT00437996","phase":"PHASE3","title":"Comparative Affect of a Continuous Epidural Infusion of Clonidine During Labour. Prospective Double Blind Randomized Trial","status":"COMPLETED","sponsor":"Hospices Civils de Lyon","startDate":"2007-02","conditions":"Normal Pregnancy","enrollment":85},{"nctId":"NCT00552864","phase":"PHASE4","title":"Comparison of Ropivacaine and Levobupivacaine in High Thoracic Epidural Anesthesia","status":"COMPLETED","sponsor":"Centro Cardiologico Monzino","startDate":"2003-01","conditions":"Coronary Artery Bypass, Epidural Anesthesia","enrollment":61}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Levobupivacaine plus sufentanil epidural infusion","genericName":"Levobupivacaine plus sufentanil epidural infusion","companyName":"University of Genova","companyId":"university-of-genova","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Levobupivacaine blocks sodium channels to provide local anesthesia, while sufentanil is an opioid agonist that enhances analgesia through mu-receptor activation, delivered together via epidural infusion for pain management. Used for Epidural analgesia for postoperative pain management, Labor pain management, Chronic pain management via epidural infusion.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}