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Bupivacaine liposome
Bupivacaine liposome is a long-acting local anesthetic that blocks sodium channels in nerve cell membranes, with the liposomal formulation providing sustained drug release for prolonged anesthesia.
Bupivacaine liposome is a long-acting local anesthetic that blocks sodium channels in nerve cell membranes, with the liposomal formulation providing sustained drug release for prolonged anesthesia. Used for Local anesthesia and analgesia for surgical and post-operative pain management.
At a glance
| Generic name | Bupivacaine liposome |
|---|---|
| Also known as | Quadratus lumborum block, Exparel, 72 hour Bupivacaine, Long acting Bupivacaine, peripheral nerve block |
| Sponsor | Tianjin Medical University General Hospital |
| Drug class | Local anesthetic (liposomal formulation) |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is an amide-type local anesthetic that inhibits sodium influx into nerve cells, preventing depolarization and action potential propagation. The liposomal encapsulation extends the duration of action by providing controlled, sustained release of the drug at the injection site, reducing the frequency of dosing and maintaining anesthetic effect for extended periods.
Approved indications
- Local anesthesia and analgesia for surgical and post-operative pain management
Common side effects
- Injection site reactions
- Transient neurological symptoms
- Systemic toxicity (at high doses)
- Hypotension
- Bradycardia
Key clinical trials
- EOIFP Block Versus OSTAP Block for Upper Abdominal Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- Effects of Erector Spinae Plane Block on Postoperative Pain Following Lumbar Fusion Surgery (NA)
- Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG) (PHASE4)
- Liposomal Bupivacaine With Standard Bupivacaine Versus Dexmedetomidine With Standard Bupivacaine (PHASE3)
- A Study of Bupivacaine Liposome Injection in the Treatment of Pain After Thoracoscopic Surgery (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine liposome CI brief — competitive landscape report
- Bupivacaine liposome updates RSS · CI watch RSS
- Tianjin Medical University General Hospital portfolio CI