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Systemic Dexamethasone plus perineural bupivacaine
Systemic dexamethasone reduces inflammation while perineural bupivacaine provides local anesthetic blockade of nerve conduction at the injection site.
Systemic dexamethasone reduces inflammation while perineural bupivacaine provides local anesthetic blockade of nerve conduction at the injection site. Used for Perineural nerve blocks with adjunctive anti-inflammatory effect (specific indication not clearly defined in available literature).
At a glance
| Generic name | Systemic Dexamethasone plus perineural bupivacaine |
|---|---|
| Sponsor | Sherif Mohamed Abd el moneim Soaida, MD |
| Drug class | Combination therapy: corticosteroid + local anesthetic |
| Target | Glucocorticoid receptor (dexamethasone); voltage-gated sodium channels (bupivacaine) |
| Modality | Small molecule |
| Therapeutic area | Pain management / Regional anesthesia |
| Phase | FDA-approved |
Mechanism of action
Dexamethasone is a corticosteroid that suppresses systemic inflammatory responses by inhibiting cytokine production and immune cell activation. Bupivacaine is a local anesthetic that blocks sodium channels in nerve membranes, preventing action potential propagation and pain signal transmission. When combined perineural (around the nerve), this approach aims to provide both local anesthesia and reduce inflammation-mediated nerve injury or pain.
Approved indications
- Perineural nerve blocks with adjunctive anti-inflammatory effect (specific indication not clearly defined in available literature)
Common side effects
- Local anesthetic toxicity (CNS or cardiac)
- Hyperglycemia (dexamethasone)
- Infection at injection site
- Nerve injury
Key clinical trials
- Does Perineural Dexamethasone Increase the Duration of an Ulnar Nerve Block When Controlling for Systemic Effects? (PHASE2)
- Perineural Steroids for Peripheral Nerve Blocks (PHASE4)
- Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty (NA)
- Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries (PHASE4)
- Comparison Between Perineural and Systemic Effect of Dexamethasone for Interscalene Brachial Plexus Block. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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