{"id":"systemic-dexamethasone-plus-perineural-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Local anesthetic toxicity (CNS or cardiac)"},{"rate":null,"effect":"Hyperglycemia (dexamethasone)"},{"rate":null,"effect":"Infection at injection site"},{"rate":null,"effect":"Nerve injury"}]},"_chembl":{"chemblId":"CHEMBL1098","moleculeType":"Small molecule","molecularWeight":"288.44"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Dexamethasone is a corticosteroid that suppresses systemic inflammatory responses by inhibiting cytokine production and immune cell activation. Bupivacaine is a local anesthetic that blocks sodium channels in nerve membranes, preventing action potential propagation and pain signal transmission. When combined perineural (around the nerve), this approach aims to provide both local anesthesia and reduce inflammation-mediated nerve injury or pain.","oneSentence":"Systemic dexamethasone reduces inflammation while perineural bupivacaine provides local anesthetic blockade of nerve conduction at the injection site.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T00:10:34.817Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Perineural nerve blocks with adjunctive anti-inflammatory effect (specific indication not clearly defined in available literature)"}]},"trialDetails":[{"nctId":"NCT04817982","phase":"PHASE2","title":"Does Perineural Dexamethasone Increase the Duration of an Ulnar Nerve Block When Controlling for Systemic Effects?","status":"COMPLETED","sponsor":"Zealand University Hospital","startDate":"2021-04-07","conditions":"Anesthesia, Local","enrollment":16},{"nctId":"NCT02462148","phase":"PHASE4","title":"Perineural Steroids for Peripheral Nerve Blocks","status":"COMPLETED","sponsor":"Wake Forest University Health Sciences","startDate":"2015-07","conditions":"Osteoarthritis, Knee","enrollment":85},{"nctId":"NCT02253784","phase":"NA","title":"Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty","status":"COMPLETED","sponsor":"Hillel Yaffe Medical Center","startDate":"2014-10","conditions":"Analgesia, Pain, Postoperative","enrollment":90},{"nctId":"NCT02576782","phase":"PHASE4","title":"Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries","status":"COMPLETED","sponsor":"Sherif Mohamed Abd el moneim Soaida, MD","startDate":"2013-06","conditions":"Pain","enrollment":63},{"nctId":"NCT02190760","phase":"NA","title":"Comparison Between Perineural and Systemic Effect of Dexamethasone for Interscalene Brachial Plexus Block.","status":"UNKNOWN","sponsor":"Hillel Yaffe Medical Center","startDate":"2014-09","conditions":"Analgesia","enrollment":90}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Systemic Dexamethasone plus perineural bupivacaine","genericName":"Systemic Dexamethasone plus perineural bupivacaine","companyName":"Sherif Mohamed Abd el moneim Soaida, MD","companyId":"sherif-mohamed-abd-el-moneim-soaida-md","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Systemic dexamethasone reduces inflammation while perineural bupivacaine provides local anesthetic blockade of nerve conduction at the injection site. Used for Perineural nerve blocks with adjunctive anti-inflammatory effect (specific indication not clearly defined in available literature).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}