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Digital nerve block with bupivacaine
Bupivacaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia in the digital nerves.
Bupivacaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia in the digital nerves. Used for Digital nerve block for surgical anesthesia of fingers or toes, Pain management during digital procedures.
At a glance
| Generic name | Digital nerve block with bupivacaine |
|---|---|
| Sponsor | Tehran University of Medical Sciences |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine is a long-acting local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. When injected around digital nerves, it prevents depolarization and conduction of pain signals, resulting in sensory and motor blockade of the fingers or toes. The effect is localized to the injection site and is reversible as the drug is metabolized and redistributed.
Approved indications
- Digital nerve block for surgical anesthesia of fingers or toes
- Pain management during digital procedures
Common side effects
- Transient paresthesia
- Temporary motor weakness
- Systemic toxicity (if intravascular injection)
- Allergic reaction
Key clinical trials
- Intercostal Nerve Block for Pain Management After Uniportal Video-assisted Thoracoscopic Surgeries (NA)
- Non-invasive Perioperative Hb Monitoring in Spinal Surgery (PHASE4)
- The Influence of a Bupivacaine Digital Nerve Block Using Rev G. (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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