{"id":"digital-nerve-block-with-bupivacaine","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient paresthesia"},{"rate":null,"effect":"Temporary motor weakness"},{"rate":null,"effect":"Systemic toxicity (if intravascular injection)"},{"rate":null,"effect":"Allergic reaction"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Bupivacaine is a long-acting local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. When injected around digital nerves, it prevents depolarization and conduction of pain signals, resulting in sensory and motor blockade of the fingers or toes. The effect is localized to the injection site and is reversible as the drug is metabolized and redistributed.","oneSentence":"Bupivacaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia in the digital nerves.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:35:17.970Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Digital nerve block for surgical anesthesia of fingers or toes"},{"name":"Pain management during digital procedures"}]},"trialDetails":[{"nctId":"NCT06838026","phase":"NA","title":"Intercostal Nerve Block for Pain Management After Uniportal Video-assisted Thoracoscopic Surgeries","status":"NOT_YET_RECRUITING","sponsor":"Al-Quds University","startDate":"2025-05-05","conditions":"Thoracic, Pain, Postoperative, Analgesia","enrollment":90},{"nctId":"NCT02908412","phase":"PHASE4","title":"Non-invasive Perioperative Hb Monitoring in Spinal Surgery","status":"COMPLETED","sponsor":"Tehran University of Medical Sciences","startDate":"2017-01-04","conditions":"Blood Loss, Surgical","enrollment":23},{"nctId":"NCT01750554","phase":"NA","title":"The Influence of a Bupivacaine Digital Nerve Block Using Rev G.","status":"COMPLETED","sponsor":"University of California, San Francisco","startDate":"2012-12","conditions":"Patients Undergoing Spine Surgery","enrollment":19}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Digital nerve block with bupivacaine","genericName":"Digital nerve block with bupivacaine","companyName":"Tehran University of Medical Sciences","companyId":"tehran-university-of-medical-sciences","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Bupivacaine blocks sodium channels in nerve fibers, preventing the generation and propagation of action potentials to produce local anesthesia in the digital nerves. Used for Digital nerve block for surgical anesthesia of fingers or toes, Pain management during digital procedures.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}