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Bupivacaine FNB
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve fibers, preventing the initiation and conduction of nerve impulses. Used for Infiltration anesthesia and nerve block in adults, Interscalene brachial plexus nerve block for shoulder surgery, Femoral nerve block for knee surgery.
At a glance
| Generic name | Bupivacaine FNB |
|---|---|
| Also known as | Bupivacaine |
| Sponsor | Pacira Pharmaceuticals, Inc |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Pain Management / Regional Anesthesia |
| Phase | FDA-approved |
Mechanism of action
Bupivacaine penetrates the nerve sheath and reversibly binds to sodium channels on the inner surface of the nerve cell membrane, inhibiting sodium influx and preventing depolarization. This blocks action potential generation and propagation in sensory and motor nerves. The FNB formulation (liposomal bupivacaine) provides extended duration of action through sustained release from lipid vesicles.
Approved indications
- Infiltration anesthesia and nerve block in adults
- Interscalene brachial plexus nerve block for shoulder surgery
- Femoral nerve block for knee surgery
- Sciatic nerve block for lower extremity surgery
Common side effects
- Hypotension
- Bradycardia
- Nausea
- Dizziness
- Headache
- Systemic toxicity (CNS or cardiac)
Key clinical trials
- Ultrasound-Guided PENG Block vs Femoral Nerve Block for Analgesia Before Spinal Anesthesia in Hip Fracture Surgery (NA)
- Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury Surgery (NA)
- Subsartorial Nerve Block and Femoral Nerve Block in Total Knee Arthroplasty (NA)
- Comparison of Femoral Nerve Block Versus Fascia Iliaca Compartment Block for Pain Control in Traumatic Femur Fracture Repair in Pediatric Population (NA)
- Analgesia After Total Knee Arthroplasty: Peri-Articular Injection Versus Epidural + Femoral Nerve Blockade (PHASE4)
- EXPAREL Infiltration in Subjects Undergoing Femoral Nerve Block With Bupivacaine HCl for Total Knee Arthroplasty (PHASE4)
- Study to Evaluate ACB Versus FNB Early Postoperative Period Functional Outcomes After TKA (NA)
- Ultrasound Guided Lateral Femoral Cutaneous Block (LFCNB) And Femoral Nerve Block (FNB) For Postoperative Pain Control After Hip Surgery (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivacaine FNB CI brief — competitive landscape report
- Bupivacaine FNB updates RSS · CI watch RSS
- Pacira Pharmaceuticals, Inc portfolio CI