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Liposomal lidocaine
Liposomal lidocaine is a local anesthetic encapsulated in liposomes that blocks sodium channels in nerve cell membranes to prevent pain signal transmission.
Liposomal lidocaine is a local anesthetic encapsulated in liposomes that blocks sodium channels in nerve cell membranes to prevent pain signal transmission. Used for Local anesthesia for pediatric procedures, Topical anesthesia for minor surgical procedures.
At a glance
| Generic name | Liposomal lidocaine |
|---|---|
| Also known as | Maxilene™, Maxilene |
| Sponsor | The Hospital for Sick Children |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia/Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine, a local anesthetic, works by inhibiting sodium influx through voltage-gated sodium channels in nerve fibers, thereby preventing depolarization and action potential propagation. The liposomal formulation encapsulates the lidocaine to improve drug delivery, reduce systemic toxicity, and potentially enhance local tissue penetration and duration of action.
Approved indications
- Local anesthesia for pediatric procedures
- Topical anesthesia for minor surgical procedures
Common side effects
- Local irritation or erythema at application site
- Systemic toxicity (rare with liposomal formulation)
- Allergic reaction
Key clinical trials
- EXPAREL or Lidocane as Local Anesthetic in Patients Undergoing Pleuroscopy With Pleural Biopsy and Indwelling Pleural Catheter Placement (PHASE2)
- TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant (PHASE4)
- Pain Control for Undergoing Costal Cartilage Harvesting (PHASE4)
- Exparel Versus Bupivacaine in Post-operative Pain Control (PHASE4)
- Study on Repeat Liposomal Bupivacaine for Post-Surgery Pain in Anal Fistula Patients. (NA)
- Liposomal Bupivacaine Versus Lidocaine for Skin Graft Donor Site Pain (PHASE4)
- Double-Blinded Randomized Controlled Study Investigating the Efficacy of Exparel (Liposomal Bupivacaine) for Postoperative Pain Relief in Mandibular Third Molar Extractions (PHASE4)
- Anesthesia and Perioperative Neurocognitive Disorders in the Elderly Patients Undergoing Hip Fracture Surgery Platform Trial (ANDES Platform Trial) (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Liposomal lidocaine CI brief — competitive landscape report
- Liposomal lidocaine updates RSS · CI watch RSS
- The Hospital for Sick Children portfolio CI