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Lidocaine solution ("A")
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for minor surgical procedures, Topical anesthesia for wound care and pain relief, Local infiltration anesthesia.
At a glance
| Generic name | Lidocaine solution ("A") |
|---|---|
| Sponsor | Hospital Universitari de Bellvitge |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through voltage-gated sodium channels in the neuronal cell membrane. This prevents depolarization and the generation of action potentials, thereby blocking pain signal transmission along nerves. It is commonly used as a topical or injectable solution for local anesthesia in minor surgical procedures, wound care, and pain management.
Approved indications
- Local anesthesia for minor surgical procedures
- Topical anesthesia for wound care and pain relief
- Local infiltration anesthesia
Common side effects
- Localized reactions (erythema, edema, irritation)
- Systemic toxicity (tremor, dizziness, seizures) at high doses
- Allergic reactions (rare with amide lidocaine)
- Methemoglobinemia (with topical spray formulations)
Key clinical trials
- Effect of Lidocaine Infusion Versus Dexmedemidine Infusion on the Neurocognitive Function of Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography(ERCP): a Randomized, Controlled Trial. (NA)
- Effects of Different Drugs for Glottic Atomization on Postoperative Sore Throat After Thyroid Surgery (PHASE4)
- Long-term Outcomes of Lidocaine Infusions for Post-Operative Pain (LOLIPOP) Trial (PHASE3)
- Bladder Directed vs. Pelvic Floor Therapy in IC/BPS (PHASE2)
- Intravenous Lidocaine Infusion in Lumbar Fusion Surgery (NA)
- Comparison of Changes in Intra-myocardial Amino Acids During Use of Calafiore and Modified Del Nido Cardioplegia
- Subcutaneous Nitroglycerin to Facilitate Trans-radial Access. (PHASE4)
- Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Lidocaine solution ("A") CI brief — competitive landscape report
- Lidocaine solution ("A") updates RSS · CI watch RSS
- Hospital Universitari de Bellvitge portfolio CI