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Lidocaine Injectable Solution
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia.
Lidocaine blocks sodium channels in nerve cell membranes, preventing the initiation and conduction of nerve impulses to produce local anesthesia. Used for Local anesthesia for infiltration, nerve blocks, and regional anesthesia, Topical anesthesia for mucous membranes and skin.
At a glance
| Generic name | Lidocaine Injectable Solution |
|---|---|
| Sponsor | Groupe Hospitalier Diaconesses Croix Saint-Simon |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Lidocaine is a local anesthetic that works by inhibiting sodium influx through sodium-selective channels in the nerve cell membrane, thereby preventing depolarization and blocking the propagation of action potentials. This reversible blockade of nerve conduction results in loss of sensation in the injected area. The drug is commonly used for infiltration anesthesia, nerve blocks, and topical anesthesia in clinical practice.
Approved indications
- Local anesthesia for infiltration, nerve blocks, and regional anesthesia
- Topical anesthesia for mucous membranes and skin
Common side effects
- Injection site reactions (pain, erythema)
- Systemic toxicity (CNS effects: tremor, dizziness, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
Key clinical trials
- Comparison of the Effectiveness of Exercise, Dry Needling and Interfascial Block Treatments in the Treatment of Myofascial Pain Syndrome (NA)
- Subcutaneous Nitroglycerin to Facilitate Trans-radial Access. (PHASE4)
- Using Lidocaine or Dexmedetomidine to Help Control Blood Pressure Spikes From a Tourniquet During Knee Surgery (PHASE2)
- Efficacy of Autologous Conditioned Serum in Temporomandibular Joint Disorder (NA)
- Effects of Dextrose Prolotherapy in Rotator Cuff Disease (NA)
- Study Evaluating the Efficacy and Safety of Chloroprocaine HCl Ophthalmic Gel 3% vs Proparacaine Ophthalmic Solution 0.5% Plus Subconjunctival Lidocaine in Patients Undergoing Intravitreal Injections (PHASE4)
- The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients (PHASE3)
- Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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