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Caudal block with levobupivacaine
Levobupivacaine administered via caudal block provides regional anesthesia by blocking sodium channels in nerve fibers, preventing pain signal transmission to the central nervous system.
Levobupivacaine administered via caudal block provides regional anesthesia by blocking sodium channels in nerve fibers, preventing pain signal transmission to the central nervous system. Used for Regional anesthesia via caudal epidural block for surgical procedures, Pain management in pediatric and adult patients.
At a glance
| Generic name | Caudal block with levobupivacaine |
|---|---|
| Sponsor | University of Novi Sad |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Levobupivacaine is the S-enantiomer of bupivacaine, a local anesthetic that reversibly inhibits sodium influx through voltage-gated sodium channels in nerve cell membranes. When delivered via caudal epidural injection, it anesthetizes sacral and lower lumbar nerve roots, providing regional anesthesia for surgical procedures and pain management. The S-enantiomer formulation offers improved cardiac safety compared to racemic bupivacaine.
Approved indications
- Regional anesthesia via caudal epidural block for surgical procedures
- Pain management in pediatric and adult patients
Common side effects
- Hypotension
- Bradycardia
- Headache
- Nausea
- Neurological complications (rare)
Key clinical trials
- Preoperative Use of Peripheral Nerve Blocks in Elderly Patients With Hip Fractures (PHASE4)
- Comparison of Loco-regional Analgesic Techniques in Patients Undergoing Video Assisted Thoracoscopic Surgery (VATS) (NA)
- Comparison of Caudal Blockade and Dorsal Penile Nerve Block With and Without the Intravenous Administration of Dexamethasone for Analgesia After Paediatric Male Circumcision (PHASE4)
- Caudal Block for Inguinal Hernioplasty in Children (PHASE3)
- Erector Spinae Plane Block Versus Serratus Anterior Block on Post Mastectomy Pain Syndrome (NA)
- Ultrasound- Guided Mid Point Transverse Process to Pleura Block (NA)
- Analgesic Efficacy of Ropivacaine Alone or in Combination With Adjuvants on Post-operative Analgesia Following Video-Assisted Thoracoscopic Surgery. (PHASE4)
- Analgesic Efficacy of U/S Retrolaminar Block and Erector Spinae Plane Block in MRM (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |