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Bupivicaine alone
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses.
Bupivacaine is a local anesthetic that blocks sodium channels in nerve cell membranes, preventing the initiation and propagation of nerve impulses. Used for Local anesthesia for infiltration, nerve block, and regional anesthesia procedures.
At a glance
| Generic name | Bupivicaine alone |
|---|---|
| Sponsor | The Cleveland Clinic |
| Drug class | Local anesthetic |
| Target | Voltage-gated sodium channels |
| Modality | Small molecule |
| Therapeutic area | Anesthesia |
| Phase | Phase 3 |
Mechanism of action
Bupivacaine reversibly binds to and blocks voltage-gated sodium channels on the inner surface of nerve cell membranes, preventing depolarization and action potential generation. This results in local anesthesia and loss of sensation in the area where it is administered. The drug has a relatively long duration of action compared to other local anesthetics due to its high lipophilicity and protein binding.
Approved indications
- Local anesthesia for infiltration, nerve block, and regional anesthesia procedures
Common side effects
- Systemic toxicity (CNS effects: tremor, seizures)
- Cardiovascular effects (hypotension, arrhythmias)
- Allergic reactions
- Methemoglobinemia
- Transient neurological symptoms
Key clinical trials
- Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy (PHASE1, PHASE2)
- TAP Blocks With Ropivacaine Continuous Infusion Catheters vs Single Dose Liposomal Bupivicaine After Kidney Transplant (PHASE4)
- Post Operative Infusion Pump Pain Study (PHASE4)
- Erector Spinae Plane (ESP) Block vs Intravenous Lignocaine Infusion in (VATS) (NA)
- Dexmedetomidine as an Adjuvant to Bupivacaine for Ultrasound-Guided External Oblique Intercostal Block (NA)
- Exparel Versus Bupivacaine in Post-operative Pain Control (PHASE4)
- Stellate Ganglion Block in the Treatment of Posttraumatic Stress Disorder (PHASE3)
- Local Anesthetic as Single Shot Versus Catheter in Patients Undergoing Video Assisted Thoracoscopic Surgery (PHASE2)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Bupivicaine alone CI brief — competitive landscape report
- Bupivicaine alone updates RSS · CI watch RSS
- The Cleveland Clinic portfolio CI