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LRA Loco-regional anesthesia
LRA delivers local anesthetic agents directly to a specific anatomical region to block nerve conduction and provide regional anesthesia for surgical or procedural pain control.
LRA delivers local anesthetic agents directly to a specific anatomical region to block nerve conduction and provide regional anesthesia for surgical or procedural pain control. Used for Regional anesthesia for surgical procedures, Perioperative pain management.
At a glance
| Generic name | LRA Loco-regional anesthesia |
|---|---|
| Also known as | 40ml Ropivacaine 0.2% |
| Sponsor | University Hospital, Angers |
| Drug class | Local anesthetic |
| Modality | Small molecule |
| Therapeutic area | Anesthesiology |
| Phase | Phase 3 |
Mechanism of action
Loco-regional anesthesia (LRA) involves the injection of local anesthetic drugs (such as lidocaine, bupivacaine, or ropivacaine) into or around nerves or tissue planes in a localized area, rather than systemic administration. This approach blocks sodium channels in nerve membranes, preventing action potential propagation and thereby eliminating sensation in the targeted region while preserving consciousness and minimizing systemic side effects.
Approved indications
- Regional anesthesia for surgical procedures
- Perioperative pain management
Common side effects
- Transient nerve injury
- Local tissue toxicity
- Systemic local anesthetic toxicity (if absorbed)
- Hematoma or bleeding at injection site
Key clinical trials
- Pain Reduction in Maxillomandibular Surgery Using Maxillary and Mandibular Nerve Blocks (NA)
- Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study) (PHASE3)
- Rotator Cuff Repair Under Isolated Loco-regional Anesthesia (NA)
- Effects of the Bilateral Mandibular Nerve Block (V3) in Mandibular Osteotomy (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- LRA Loco-regional anesthesia CI brief — competitive landscape report
- LRA Loco-regional anesthesia updates RSS · CI watch RSS
- University Hospital, Angers portfolio CI