{"id":"lra-loco-regional-anesthesia","safety":{"commonSideEffects":[{"rate":null,"effect":"Transient nerve injury"},{"rate":null,"effect":"Local tissue toxicity"},{"rate":null,"effect":"Systemic local anesthetic toxicity (if absorbed)"},{"rate":null,"effect":"Hematoma or bleeding at injection site"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Loco-regional anesthesia (LRA) involves the injection of local anesthetic drugs (such as lidocaine, bupivacaine, or ropivacaine) into or around nerves or tissue planes in a localized area, rather than systemic administration. This approach blocks sodium channels in nerve membranes, preventing action potential propagation and thereby eliminating sensation in the targeted region while preserving consciousness and minimizing systemic side effects.","oneSentence":"LRA delivers local anesthetic agents directly to a specific anatomical region to block nerve conduction and provide regional anesthesia for surgical or procedural pain control.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:19:42.162Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Regional anesthesia for surgical procedures"},{"name":"Perioperative pain management"}]},"trialDetails":[{"nctId":"NCT05351151","phase":"NA","title":"Pain Reduction in Maxillomandibular Surgery Using Maxillary and Mandibular Nerve Blocks","status":"COMPLETED","sponsor":"University Hospital, Toulouse","startDate":"2022-05-23","conditions":"Pain, Post Operative, Regional Anesthesia","enrollment":50},{"nctId":"NCT05345639","phase":"PHASE3","title":"Chest Wall Block After Sternotomy: Randomized Controlled Trial in Cardiac Surgery: (PABLOS Study)","status":"COMPLETED","sponsor":"University Hospital, Angers","startDate":"2022-08-01","conditions":"Pain, Postoperative, Cardiac Surgery","enrollment":254},{"nctId":"NCT05848375","phase":"NA","title":"Rotator Cuff Repair Under Isolated Loco-regional Anesthesia","status":"RECRUITING","sponsor":"Elsan","startDate":"2023-11-13","conditions":"Shoulder Cuff Surgical Repair","enrollment":80},{"nctId":"NCT02618993","phase":"PHASE3","title":"Effects of the Bilateral Mandibular Nerve Block (V3) in Mandibular Osteotomy","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2015-12","conditions":"Mandibular Fracture Trauma, Orthognathic Surgery, Maxillofacial Osteotomy","enrollment":108}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":6,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["40ml Ropivacaine 0.2%"],"phase":"phase_3","status":"active","brandName":"LRA Loco-regional anesthesia","genericName":"LRA Loco-regional anesthesia","companyName":"University Hospital, Angers","companyId":"university-hospital-angers","modality":"Small molecule","firstApprovalDate":"","aiSummary":"LRA delivers local anesthetic agents directly to a specific anatomical region to block nerve conduction and provide regional anesthesia for surgical or procedural pain control. Used for Regional anesthesia for surgical procedures, Perioperative pain management.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}