Opioid analgesic

This page covers all Opioid analgesic drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Opioid receptors (mu, delta, kappa), Mu (μ) opioid receptor, Mu-opioid receptor (μ-OR).

Targets

Opioid receptors (mu, delta, kappa) · Mu (μ) opioid receptor · Mu-opioid receptor (μ-OR) · mu-opioid receptor · Mu-opioid receptor (OPRM1) · Mu opioid receptor (μ-OR) · Mu opioid receptor (primary); delta and kappa opioid receptors (secondary) · Mu-opioid receptor (μ-opioid receptor) · Mu-opioid receptor (OPRM1); tapentadol also targets norepinephrine transporter (SLC6A2) · Mu-opioid receptor

Marketed (60)

• Analgesic, Opioid · Virgilio Paolo Carnielli · Pain management
  Opioid analgesics bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and transmission.
• Oxycodone(single compound) · Mundipharma Korea Ltd · Pain Management
  Oxycodone binds to opioid receptors in the central nervous system to block pain signal transmission and produce analgesia.
• I/T morphine · Region Örebro County · Pain management
  Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.
• MEPERIDINE · Metabolic
  Meperidine is an opioid agonist that binds to mu-opioid receptors to produce analgesia and sedation.
• Postop hydromorphone IV · AdventHealth · Pain Management
  Hydromorphone is a mu-opioid receptor agonist that binds to opioid receptors in the central nervous system to produce analgesia and sedation.
• HYD · Purdue Pharma LP · Pain Management
  Hydrocodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and cough suppression.
• Intravenous morphine and oral oxycodone · University of Puerto Rico · Pain management
  Morphine and oxycodone are opioid agonists that bind to mu-opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
• Standard Care morphine hydrochloride · Centre Hospitalier Universitaire de Nīmes · Pain management
  Morphine hydrochloride binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.
• Standard Opioid · Prisma Health-Upstate · Pain Management
  Standard opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and produce analgesia.
• Transdermal fentanyl patch · Tel-Aviv Sourasky Medical Center · Pain management
  Transdermal fentanyl delivers the opioid fentanyl through the skin at a controlled rate to bind mu-opioid receptors in the central nervous system and reduce pain perception.
• IV Fentanyl · University of Minnesota · Pain Management
  IV Fentanyl is a potent synthetic opioid that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
• Conventional oral morphine · Children's Hospital of Fudan University · Pain management
  Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.
• Morphine Retard · Huib A.M. Kerstjens · Pain Management
  Morphine Retard is a sustained-release formulation of morphine that binds to opioid receptors in the central nervous system to provide prolonged pain relief.
• morphine sulphate in intrasite gel · Institute of Child Health · Pain management
  Morphine sulphate in intrasite gel delivers the opioid analgesic morphine topically to provide localized pain relief through mu-opioid receptor activation.
• Sufentanil Sublingual Tablet · Centre Hospitalier Universitaire de Tivoli · Pain Management
  Sufentanil is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
• Sustained Release Morphine Sulfate · Labtec GmbH · Pain Management
  Sustained-release morphine sulfate binds to opioid receptors in the central nervous system to provide prolonged pain relief.
• tapentadol, oxycodone · University Hospital Schleswig-Holstein · Pain Management
  Tapentadol and oxycodone are opioid analgesics that bind to mu-opioid receptors in the central nervous system to reduce pain perception; tapentadol also inhibits norepinephrine reuptake.
• Morphine Patient Controlled Analgesia · Istituti Ospitalieri di Cremona · Pain Management
  Morphine binds to opioid receptors in the central nervous system to block pain signal transmission and provide analgesia.
• Morphine intravenous · Charles University, Czech Republic · Pain management
  Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria.
• MS Contin · National Institute of Nursing Research (NINR) · Pain Management
  MS Contin is a sustained-release formulation of morphine sulfate that binds to opioid receptors in the central nervous system to reduce pain perception.
• Opioid Analgesic · Vanderbilt University Medical Center · Pain Management
  Opioid analgesics bind to opioid receptors in the central and peripheral nervous system to reduce the perception of pain.
• Opium tincture · Asbjørn Mohr Drewes · Pain management; Gastroenterology
  Opium tincture contains alkaloids (primarily morphine and codeine) that bind to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and antidiarrheal effects.
• Postop oral oxycodone · AdventHealth · Pain Management
  Oxycodone binds to opioid receptors in the central nervous system to block pain signal transmission and provide analgesia.
• Darvocet then placebo then opana · University of Rochester · Pain Management
  This is a study comparing three opioid pain medications: Darvocet (propoxyphene/acetaminophen), placebo, and Opana (oxymorphone), to evaluate their relative efficacy and safety in pain management.
• MS Contin · Generic (multiple manufacturers) · Pain
  The prototypical opioid agonist that binds mu-opioid receptors in the CNS, providing potent analgesia and serving as the reference standard for all opioids.
• Group O (Oxycodone) · Medical University of Silesia · Pain Management
  Oxycodone is a semi-synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and pain relief.
• morphine solution for injection · Danish University of Pharmaceutical Sciences · Pain management
  Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria.
• Individualized oral morphine · Children's Hospital of Fudan University · Pain management
  Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.
• liquid oxycodone · Boston Children's Hospital · Pain Management
  Oxycodone is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.
• standard opioid prescribing · Walter Reed National Military Medical Center · Pain Management
  Opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and emotional response to pain.
• Morphine p.o. · Brigham and Women's Hospital · Pain Management
  Morphine binds to opioid receptors in the central nervous system to reduce pain perception and produce analgesia.
• Fentanyl Analgesic regimen · Ain Shams University · Pain Management
  Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and pain relief.
• Fentanyl/Placebo injection · University Hospital, Bordeaux · Pain management / Anesthesia
  Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
• Spinal Hydromorphone · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Pain Management
  Spinal hydromorphone is an opioid analgesic that binds to opioid receptors in the spinal cord to block pain signal transmission.
• Oxycodone intravenously · Kuopio University Hospital · Pain Management
  Oxycodone binds to opioid receptors in the central nervous system to block pain signal transmission and produce analgesia.
• Preservative-free epidural morphine · Mount Sinai Hospital, Canada · Pain Management
  Morphine binds to opioid receptors in the spinal cord and brain to block pain signal transmission and provide analgesia.
• morphine mouthwash · Danish University of Pharmaceutical Sciences · Pain Management
  Morphine mouthwash delivers the opioid analgesic morphine topically to oral mucosa to relieve oral pain and discomfort.
• Opioid-Containing · OrthoCarolina Research Institute, Inc. · Pain Management
  Opioid-containing formulations bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and transmission.
• opioid pain pills · Rush University Medical Center · Pain Management
  Opioid pain pills bind to opioid receptors in the central and peripheral nervous system to reduce the perception of pain.
• Controlled Release Morphine · Nova Scotia Health Authority · Pain Management
  Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.

Phase 3 pipeline (34)

• OxyNorm Capsules · Mundipharma (China) Pharmaceutical Co. Ltd · Pain Management
  OxyNorm is an immediate-release oral formulation of oxycodone, a mu-opioid receptor agonist that binds to opioid receptors in the central nervous system to produce analgesia and other opioid effects.
• Hydromorphone, liquid oral · University of British Columbia · Pain Management
  Hydromorphone is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.
• Morphine Sulphate Controlled Release · Grünenthal GmbH · Pain Management
  Morphine sulphate is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and pain relief.
• Active Comparator: Morphine · Shanghai Haiyan Pharmaceutical Technology Co., Ltd. · Pain Management
  Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.
• Sufentanil + Lidocaïne · University Hospital, Montpellier · Pain management
  Sufentanil is a potent opioid analgesic that acts as a mu-opioid receptor agonist, while Lidocaïne is a local anesthetic that blocks sodium channels.
• Morphine Sulfate Sustained-release Tablets · Fujian Cancer Hospital · Oncology; Pain Management
  Morphine sulfate binds to opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
• acetaminophen plus codeine · Nova Scotia Health Authority · Pain management
  Acetaminophen acts as a non-selective COX inhibitor, while codeine exerts its effects through opioid receptors.
• Immediate release morphine sulphate · Archimedes Development Ltd · Pain management
  Morphine sulphate binds to opioid receptors in the central and peripheral nervous system to produce analgesia and sedation.
• Fentanyl Buccal Tablet · M.D. Anderson Cancer Center · Oncology
  Fentanyl buccal tablet delivers the opioid fentanyl through the buccal mucosa to provide rapid analgesia by binding to mu opioid receptors in the central nervous system.
• Fixed opioid prescription · The George Washington University Biostatistics Center · Pain Management
  A fixed-dose opioid formulation designed to provide consistent pain relief through standardized dosing of opioid analgesics.
• Oral immediate-released morphine · Fujian Cancer Hospital · Oncology, Pain Management
  Morphine binds to opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
• PCA with Chlorhydrate of Morphine · Centre Hospitalier Universitaire de Besancon · Pain Management
  Morphine hydrochloride delivered via patient-controlled analgesia (PCA) allows patients to self-administer opioid doses on demand for pain relief.
• Panadeine® Extra · Reckitt Benckiser LLC · Pain management
  Panadeine Extra contains paracetamol and codeine, which work together to relieve pain and reduce fever.
• BEMA Fentanyl · BioDelivery Sciences International · Pain Management
  BEMA Fentanyl is a fentanyl formulation delivered via a buccal mucoadhesive patch that provides rapid opioid analgesia for breakthrough pain.
• E-TRANS Fentanyl hydrochloride; Morphine · Alza Corporation, DE, USA · Pain Management
  E-TRANS is a transdermal delivery system that provides sustained release of fentanyl and morphine, potent opioid agonists that bind to mu opioid receptors in the central nervous system to produce analgesia and pain relief.
• Tramadol HCl Twice a day · Labopharm Inc. · Pain management
  Tramadol HCl is a centrally acting opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, reducing pain perception.
• Tramadol HCl Contramid® Once A Day · Labopharm Inc. · Pain management
  Tramadol HCl is a centrally acting opioid analgesic that works by binding to mu-opioid receptors in the brain.
• Opioid administration oxycodone · KK Women's and Children's Hospital · Pain Management
  Oxycodone binds to opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
• Tramadol Once A Day · Labopharm Inc. · Pain management
  Tramadol is a centrally acting opioid analgesic that works by binding to opioid receptors in the brain and spinal cord.
• Tramadol (Ultram®) · Esteve Pharmaceuticals, S.A. · Pain management
  Tramadol is a centrally acting opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, reducing pain perception.
• Hydromorphone, Injectable · University of British Columbia · Pain Management
  Hydromorphone is a mu-opioid receptor agonist that binds to opioid receptors in the central nervous system to produce analgesia and pain relief.
• OROS hydromorphone HCL ; OxyContin · Alza Corporation, DE, USA · Pain management
  OROS hydromorphone HCL is a long-acting opioid analgesic that works by binding to opioid receptors in the brain, spinal cord, and other areas of the body.
• OROS Hydromorphone HCI · Alza Corporation, DE, USA · Pain Management
  OROS Hydromorphone HCI is an extended-release opioid agonist that binds to mu-opioid receptors in the central nervous system to provide sustained pain relief.
• OROS hydromorphone HCL ; Morphine sulfate · Alza Corporation, DE, USA · Pain Management
  OROS hydromorphone HCl is an extended-release opioid agonist that binds to mu opioid receptors in the central nervous system to provide prolonged pain relief.
• Hydrocodone ER · Teva Branded Pharmaceutical Products R&D, Inc. · Pain Management
  Hydrocodone is an opioid agonist that binds to mu-opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
• Placebo Sufentanil NanoTab PCA System · Talphera, Inc · Pain Management
  Sufentanil is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to provide rapid pain relief via patient-controlled analgesia.
• Morphine plus Saline (placebo) · University of California, San Francisco · Pain Management
  Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception, while saline serves as an inert placebo control.
• tramacet, naloxone · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Pain management
  Tramadol is a centrally acting opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, while naloxone is an opioid antagonist that reverses opioid overdose by blocking opioid receptors.
• KW-2246 (fentanyl citrate) · Kyowa Kirin Co., Ltd. · Pain Management
  KW-2246 is a fentanyl citrate formulation that binds to opioid receptors in the central nervous system to produce analgesia and pain relief.
• Meperidine Injection · Centre hospitalier de l'Université de Montréal (CHUM) · Pain Management
  Meperidine is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.
• Fentanyl Ethypharm · Ethypharm · Pain Management
  Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
• Hydromorphone Hydrochloride Extended-Release Tablets · Qinghai Red Cross Hospital · Pain Management
  Hydromorphone hydrochloride is a semi-synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and pain relief.
• Oxycodone HCl controlled-release tablets · Purdue Pharma LP · Pain Management
  Oxycodone HCl binds to opioid receptors in the central nervous system to block pain signal transmission and provide analgesia.
• IV titration of morphine chlorhydrate · University Hospital, Rouen · Pain Management
  Morphine binds to opioid receptors in the central nervous system to produce analgesia and sedation through inhibition of pain signal transmission.

Phase 2 pipeline (4)

• ACTIQ® · Cephalon · Pain Management
  ACTIQ® delivers fentanyl, a potent opioid analgesic, directly to the oral mucosa for rapid absorption and pain relief.
• Hydromorphone HCI OROS · Janssen Korea, Ltd., Korea · Pain management
  μ-opioid receptor agonist
• Co-Codamol · GlaxoSmithKline · Pain Management
  Acts as a weak agonist at the mu-opioid receptor and a weak antagonist at the kappa-opioid receptor.
• Analgesics, Opioid · LinkCare GmbH · Oncology
  Opioid receptor agonist

Phase 1 pipeline (1)

• Actiq® 400 µg transmucosally · INSYS Therapeutics Inc · Pain Management
  Fentanyl acts by binding to opioid receptors, primarily mu-opioid receptors, in the central nervous system to produce analgesia and euphoria.