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morphine solution for injection
Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria.
Morphine binds to opioid receptors in the central and peripheral nervous system to produce analgesia, sedation, and euphoria. Used for Moderate to severe acute and chronic pain, Postoperative pain, Cancer pain.
At a glance
| Generic name | morphine solution for injection |
|---|---|
| Sponsor | Danish University of Pharmaceutical Sciences |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that modulates pain perception and emotional response to pain by binding to opioid receptors in the brain, spinal cord, and peripheral tissues. This binding inhibits the release of neurotransmitters involved in pain signaling and alters the patient's perception and emotional response to pain. The drug also produces sedation and can suppress cough and respiratory drive.
Approved indications
- Moderate to severe acute and chronic pain
- Postoperative pain
- Cancer pain
- Myocardial infarction-related pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Respiratory depression
- Pruritus
- Vomiting
Key clinical trials
- Pain Reduction for Limb Injuries in Pediatric Emergency Departments: Intranasal Fentanyl or Intranasal Ketamine vs Oral Morphine (PHASE3)
- Phase II Clinical Study of the Efficacy and Safety of HSK55718 in the Treatment of Abdominal Postoperative Pain (PHASE2)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- Efficacy and Safety of Ofatumumab and Siponimod Compared to Fingolimod in Pediatric Patients With Multiple Sclerosis (PHASE3)
- Effect of Tegileridine on Postoperative Bowel Function Recovery in Abdominal Surgery (PHASE4)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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