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opioid pain pills
Opioid pain pills bind to opioid receptors in the central and peripheral nervous system to reduce the perception of pain.
Opioid pain pills bind to opioid receptors in the central and peripheral nervous system to reduce the perception of pain. Used for Moderate to severe acute pain, Moderate to severe chronic pain.
At a glance
| Generic name | opioid pain pills |
|---|---|
| Sponsor | Rush University Medical Center |
| Drug class | Opioid analgesic |
| Target | Mu opioid receptor (primary); delta and kappa opioid receptors (secondary) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Opioids work by activating mu, delta, and kappa opioid receptors throughout the brain and spinal cord, which decreases pain signal transmission and alters emotional responses to pain. This class includes both natural opioids (morphine, codeine) and synthetic variants (oxycodone, hydrocodone, fentanyl). They are typically used for moderate to severe acute or chronic pain management.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Respiratory depression
- Dependence/addiction risk
Key clinical trials
- Open-label Placebo for Pain Management in Adolescents and Young Adults Undergoing Bernese Periacetabular Osteotomy (NA)
- Open-label Placebo (COLP) for Pain in Adolescent Idiopathic Scoliosis (AIS) Surgery+Surgical Treatment of Idiopathic Scoliosis (NA)
- Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients (PHASE2)
- Low Dose Naltrexone (LDN) for Management of Fatigue in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT) (PHASE2)
- Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses (PHASE4)
- Opioid-Free Pain Protocol After Shoulder Arthroplasty (PHASE4)
- Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction. (PHASE4)
- Opioid Consumption and Disposal After Shoulder Arthroplasty (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- opioid pain pills CI brief — competitive landscape report
- opioid pain pills updates RSS · CI watch RSS
- Rush University Medical Center portfolio CI