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Conventional oral morphine
Conventional oral morphine is a Opioid analgesic Small molecule drug developed by Children's Hospital of Fudan University. It is currently FDA-approved for Moderate to severe acute pain, Moderate to severe chronic pain, Cancer pain. Also known as: Conventional group.
Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.
Conventional oral morphine is used to treat various conditions, including inflammation, acute and chronic pain, and is also studied in the context of gastric-bypass surgery. Its mechanism of action is not explicitly stated in the provided facts, but it is likely related to its analgesic properties, which are commonly associated with morphine's interaction with opioid receptors.
At a glance
| Generic name | Conventional oral morphine |
|---|---|
| Also known as | Conventional group |
| Sponsor | Children's Hospital of Fudan University |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that crosses the blood-brain barrier and acts on opioid receptors in the brain, spinal cord, and peripheral tissues. This binding modulates pain signal transmission and produces analgesic, sedative, and euphoric effects. The conventional oral formulation provides immediate-release analgesia suitable for acute and chronic pain management.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
- Cancer pain
Common side effects
- Constipation
- Nausea
- Drowsiness
- Dizziness
- Vomiting
- Respiratory depression
- Dependence/tolerance
Key clinical trials
- A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma (PHASE3)
- Comparison of Inflammatory Factors, Pain Scale, and Postoperative Recovery Quality (QOR - 15) in Patients Undergoing Colorectal Cancer Surgery with Conventional General Anesthesia Techniques Compared to General Anesthesia Combined with Epidural Anesthesia At Prof. Ngoerah Hospital (PHASE4)
- Individualized Analgesia for Pediatric Adenotonsillectomy (PHASE4)
- Thoracolumbar Interfascial Plane Block in Lumber Spine Surgery (NA)
- Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery (NA)
- Transversus Abdominis Plane (TAP) Block in Laparoscopic Gastric-bypass Surgery (PHASE3)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Conventional oral morphine CI brief — competitive landscape report
- Conventional oral morphine updates RSS · CI watch RSS
- Children's Hospital of Fudan University portfolio CI
Frequently asked questions about Conventional oral morphine
What is Conventional oral morphine?
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Related
- Drug class: All Opioid analgesic drugs
- Target: All drugs targeting Mu-opioid receptor (μ-OR)
- Manufacturer: Children's Hospital of Fudan University — full pipeline
- Therapeutic area: All drugs in Pain management
- Indication: Drugs for Moderate to severe acute pain
- Indication: Drugs for Moderate to severe chronic pain
- Indication: Drugs for Cancer pain
- Also known as: Conventional group
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing