{"id":"conventional-oral-morphine","safety":{"commonSideEffects":[{"rate":"40-50","effect":"Constipation"},{"rate":"20-30","effect":"Nausea"},{"rate":"20-30","effect":"Drowsiness"},{"rate":"10-20","effect":"Dizziness"},{"rate":"10-15","effect":"Vomiting"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Dependence/tolerance"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that crosses the blood-brain barrier and acts on opioid receptors in the brain, spinal cord, and peripheral tissues. This binding modulates pain signal transmission and produces analgesic, sedative, and euphoric effects. The conventional oral formulation provides immediate-release analgesia suitable for acute and chronic pain management.","oneSentence":"Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T00:31:18.267Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Moderate to severe acute pain"},{"name":"Moderate to severe chronic pain"},{"name":"Cancer pain"}]},"trialDetails":[{"nctId":"NCT04994132","phase":"PHASE3","title":"A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"Children's Oncology Group","startDate":"2021-09-14","conditions":"Alveolar Rhabdomyosarcoma, Botryoid-Type Embryonal Rhabdomyosarcoma, Embryonal Rhabdomyosarcoma","enrollment":118},{"nctId":"NCT06784258","phase":"PHASE4","title":"Comparison of Inflammatory Factors, Pain Scale, and Postoperative Recovery Quality (QOR - 15) in Patients Undergoing Colorectal Cancer Surgery with Conventional General Anesthesia Techniques Compared to General Anesthesia Combined with Epidural Anesthesia At Prof. Ngoerah Hospital","status":"ACTIVE_NOT_RECRUITING","sponsor":"Udayana University","startDate":"2024-12-28","conditions":"Inflammation Biomarkers, Quality of Recovery (QoR-15), Visual Analog Pain Scale","enrollment":44},{"nctId":"NCT04527393","phase":"PHASE4","title":"Individualized Analgesia for Pediatric Adenotonsillectomy","status":"COMPLETED","sponsor":"Children's Hospital of Fudan University","startDate":"2022-05-01","conditions":"Adenotonsillectomy, Analgesia","enrollment":542},{"nctId":"NCT05880017","phase":"NA","title":"Thoracolumbar Interfascial Plane Block in Lumber Spine Surgery","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2022-12-01","conditions":"Post Operative Pain Management","enrollment":60},{"nctId":"NCT05069311","phase":"NA","title":"Effects of Multimodal Analgesia on Serum MCP-1, BDNF, and MiRNA-124 in Hysterectomy Surgery","status":"COMPLETED","sponsor":"Udayana University","startDate":"2021-10-15","conditions":"Inflammation, Inflammatory Response, Acute Pain","enrollment":62},{"nctId":"NCT01568437","phase":"PHASE3","title":"Transversus Abdominis Plane (TAP) Block in Laparoscopic Gastric-bypass Surgery","status":"COMPLETED","sponsor":"University Health Network, Toronto","startDate":"2012-01","conditions":"Gastric-bypass Surgery, Opioid Consumption, Obesity","enrollment":70}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":57,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Conventional group"],"phase":"marketed","status":"active","brandName":"Conventional oral morphine","genericName":"Conventional oral morphine","companyName":"Children's Hospital of Fudan University","companyId":"children-s-hospital-of-fudan-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Conventional oral morphine is used to treat various conditions, including inflammation, acute and chronic pain, and is also studied in the context of gastric-bypass surgery. Its mechanism of action is not explicitly stated in the provided facts, but it is likely related to its analgesic properties, which are commonly associated with morphine's interaction with opioid receptors.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":2,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}