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Meperidine Injection
Meperidine is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.
Meperidine is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation. Used for Moderate to severe acute pain, Perioperative pain management.
At a glance
| Generic name | Meperidine Injection |
|---|---|
| Also known as | demerol |
| Sponsor | Centre hospitalier de l'Université de Montréal (CHUM) |
| Drug class | Opioid analgesic |
| Target | Mu opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | Phase 3 |
Mechanism of action
Meperidine acts as a mu opioid receptor agonist, blocking pain signal transmission in the spinal cord and brain. It also has weak monoamine oxidase inhibitor and local anesthetic properties. The drug is commonly used for moderate to severe acute pain management in hospital settings.
Approved indications
- Moderate to severe acute pain
- Perioperative pain management
Common side effects
- Respiratory depression
- Nausea and vomiting
- Dizziness
- Constipation
- Sedation
- Hypotension
- Seizures (with high doses or prolonged use)
Key clinical trials
- Ultrasound-Guided Regional Blocks for Postoperative Analgesia After Laparoscopic Cholecystectomy (NA)
- Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy (NA)
- Ultrasound-Guided Adductor Canal Block for Total Knee Arthroplasty Surgery (NA)
- Para-sartorial Compartment Block in Knee Surgery (NA)
- Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors (NA)
- Comparative Study Between the Prophylactic Intravenous Administrations of Acetaminophen vs Dexamethasone vs Pethidine Regarding the Incidence of Shivering Induced by Single Shot Spinal Anesthesia in the Orthopedic Surgeries of the Lower Limbs (PHASE4)
- Comparing Prophylactic Intravenous Pethidine and Intrathecal Pethidine in Preventing Post Spinal Shivering in Caesarean Section (PHASE3)
- Comparison of the Analgesic Efficacy of Dexketoprofen Trometamol, Meperidine, and Paracetamol in Renal Colic (PHASE4)
Primary sources
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| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |