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morphine sulphate in intrasite gel
Morphine sulphate in intrasite gel delivers the opioid analgesic morphine topically to provide localized pain relief through mu-opioid receptor activation.
Morphine sulphate in intrasite gel delivers the opioid analgesic morphine topically to provide localized pain relief through mu-opioid receptor activation. Used for Localized pain relief in wounds and ulcers, Palliative care pain management.
At a glance
| Generic name | morphine sulphate in intrasite gel |
|---|---|
| Sponsor | Institute of Child Health |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (μ-OR) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Morphine is a mu-opioid receptor agonist that binds to opioid receptors in the central and peripheral nervous system to reduce pain perception. When formulated in intrasite gel, a hydrogel vehicle, morphine can be applied directly to wound surfaces or affected areas to provide localized analgesia while maintaining a moist wound environment. This topical delivery approach allows pain relief with potentially reduced systemic absorption compared to parenteral routes.
Approved indications
- Localized pain relief in wounds and ulcers
- Palliative care pain management
Common side effects
- Local skin irritation
- Allergic contact dermatitis
- Systemic opioid effects (if significant absorption)
Key clinical trials
- Retrospective Analysis of the Efficacy of Morphine Gel to Treat Pain Associated With Perineal RadioDermatitis
- Randomised Double Blind Placebo Controlled Cross Over Design of the Efficacy of Topical Morphine for Inflammatory Pain in Children With Epidermolysis Bullosa (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- morphine sulphate in intrasite gel CI brief — competitive landscape report
- morphine sulphate in intrasite gel updates RSS · CI watch RSS
- Institute of Child Health portfolio CI