{"id":"morphine-sulphate-in-intrasite-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Allergic contact dermatitis"},{"rate":null,"effect":"Systemic opioid effects (if significant absorption)"}]},"_chembl":{"chemblId":"CHEMBL5665374","moleculeType":null,"molecularWeight":"285.34"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Morphine is a mu-opioid receptor agonist that binds to opioid receptors in the central and peripheral nervous system to reduce pain perception. When formulated in intrasite gel, a hydrogel vehicle, morphine can be applied directly to wound surfaces or affected areas to provide localized analgesia while maintaining a moist wound environment. This topical delivery approach allows pain relief with potentially reduced systemic absorption compared to parenteral routes.","oneSentence":"Morphine sulphate in intrasite gel delivers the opioid analgesic morphine topically to provide localized pain relief through mu-opioid receptor activation.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:28.231Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Localized pain relief in wounds and ulcers"},{"name":"Palliative care pain management"}]},"trialDetails":[{"nctId":"NCT07207889","phase":"","title":"Retrospective Analysis of the Efficacy of Morphine Gel to Treat Pain Associated With Perineal RadioDermatitis","status":"COMPLETED","sponsor":"Institut Curie","startDate":"2024-12-01","conditions":"Dermatitis, Radiation Induced","enrollment":17},{"nctId":"NCT00231517","phase":"PHASE4","title":"Randomised Double Blind Placebo Controlled Cross Over Design of the Efficacy of Topical Morphine for Inflammatory Pain in Children With Epidermolysis Bullosa","status":"COMPLETED","sponsor":"Institute of Child Health","startDate":"","conditions":"Epidermylosis Bullosa","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"morphine sulphate in intrasite gel","genericName":"morphine sulphate in intrasite gel","companyName":"Institute of Child Health","companyId":"institute-of-child-health","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Morphine sulphate in intrasite gel delivers the opioid analgesic morphine topically to provide localized pain relief through mu-opioid receptor activation. Used for Localized pain relief in wounds and ulcers, Palliative care pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}