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Intravenous morphine and oral oxycodone
Morphine and oxycodone are opioid agonists that bind to mu-opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
Morphine and oxycodone are opioid agonists that bind to mu-opioid receptors in the central nervous system to reduce pain perception and provide analgesia. Used for Moderate to severe acute pain, Moderate to severe chronic pain.
At a glance
| Generic name | Intravenous morphine and oral oxycodone |
|---|---|
| Sponsor | University of Puerto Rico |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | FDA-approved |
Mechanism of action
Both morphine and oxycodone work by activating mu-opioid receptors throughout the brain and spinal cord, which modulates pain signal transmission and produces analgesic effects. Morphine is administered intravenously for rapid onset in acute or severe pain settings, while oxycodone is given orally for sustained pain management. Together, they represent a multimodal opioid approach to pain control.
Approved indications
- Moderate to severe acute pain
- Moderate to severe chronic pain
Common side effects
- Respiratory depression
- Constipation
- Nausea and vomiting
- Drowsiness and sedation
- Dizziness
- Dependence and addiction risk
Key clinical trials
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Transversus Abdominis Plane Block in Relieving Postoperative Pain After Laparoscopic Surgery in Gynecologic Oncology (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Laparoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Hemorrhoid Surgery (NA)
- The Efficacy and Safety of Liposomal Bupivacaine for Rhomboid Intercostal Nerve Block in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery (NA)
- IV vs Oral Acetaminophen in Spine Fusion Perioperative Care (PHASE4)
- Postoperative Pain Management in Patients Undergoing Intramedullary Nail Fixation After Tibia and Femoral Fractures (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
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