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IV Fentanyl
IV Fentanyl is a potent synthetic opioid that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation.
IV Fentanyl is a potent synthetic opioid that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. Used for Acute pain management in hospitalized patients, Procedural sedation and analgesia, Perioperative analgesia.
At a glance
| Generic name | IV Fentanyl |
|---|---|
| Also known as | Fentanyl Citrate Injection |
| Sponsor | University of Minnesota |
| Drug class | Opioid analgesic |
| Target | Mu-opioid receptor (OPRM1) |
| Modality | Small molecule |
| Therapeutic area | Pain Management |
| Phase | FDA-approved |
Mechanism of action
Fentanyl acts as an agonist at mu-opioid receptors, which are G-protein coupled receptors distributed throughout the brain and spinal cord. This binding modulates pain perception and produces sedative effects. The intravenous formulation allows for rapid onset and precise titration, making it suitable for acute pain management and procedural sedation in hospital settings.
Approved indications
- Acute pain management in hospitalized patients
- Procedural sedation and analgesia
- Perioperative analgesia
Common side effects
- Respiratory depression
- Hypotension
- Bradycardia
- Nausea and vomiting
- Dizziness
- Chest wall rigidity
Key clinical trials
- A Phase 2 Safety, Tolerability, PK, and Efficacy Study of CS-1103 Following Fentanyl Challenge With Naloxone Blockade (PHASE2)
- Comparison of Fentanyl and Magnesium to Control Reflex Hemodynamics in Patients Aged 50 and Older (NA)
- Safety and Efficacy of Dexmedetomidate vs. Midazolam for Procedural Sedation During Medical Thoracoscopy (PHASE3)
- Oliceridine Versus Sufentanil for Postoperative Nausea in Cerebellopontine Angle Surgery (NA)
- The Impact of a Shared Decision-Making Intervention on Intraoperative Patient Experience During Elective Cesarean Delivery Under Spinal Anesthesia (NA)
- Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass (NA)
- Premedication for Less Invasive Surfactant Administration Study (PRELISA) (PHASE4)
- Symptom-inhibited Fentanyl Induction (PHASE4)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- IV Fentanyl CI brief — competitive landscape report
- IV Fentanyl updates RSS · CI watch RSS
- University of Minnesota portfolio CI