Mu-opioid receptor — Drug Target

All drugs that target Mu-opioid receptor — marketed and clinical-stage. Includes 21 drug classes acting on this target.

Drug classes

Opioid agonist · opioid · Opioid Agonist · Opioid agonist or antagonist · Opioid analgesic · Opioid antagonist · Opioid analgesic, abuse-deterrent formulation · Opioid · opioid analgesic · Opioid analgesic (mu-opioid receptor agonist) · Opioid agonist (with behavioral intervention) · Opioid analgesic (abuse-deterrent formulation)

Marketed (19)

• OROS hydromorphone HCl · Janssen-Cilag International NV · Opioid agonist · Pain Management
  OROS hydromorphone HCl is an extended-release opioid agonist that binds to mu-opioid receptors in the central nervous system to provide sustained pain relief.
• PS · yangjie · opioid · Pain management
  PS is a synthetic opioid analgesic that acts as a mu-opioid receptor agonist.
• Dilaudid-Hp · Fresenius Kabi · Opioid Agonist · Neuroscience
  Hydromorphone binds primarily to mu-opioid receptors, producing analgesia without a ceiling effect.
• Levo-Dromoran · Bausch Health · Opioid Agonist · Neuroscience
  Levorphanol binds primarily to mu-opioid receptors to produce analgesia, with no ceiling effect for pain relief.
• medication for opioid use disorder · University of Pennsylvania · Opioid agonist or antagonist · Psychiatry / Addiction Medicine
  Opioid use disorder medications work by binding to opioid receptors to reduce cravings, prevent withdrawal, or block the euphoric effects of opioids.
• Split dose of methadone · Wake Forest University Health Sciences · Opioid agonist · Addiction Medicine / Pain Management
  Split-dose methadone divides the daily methadone dose into multiple administrations to optimize plasma levels and reduce peak-trough fluctuations.
• Dilaudid-Hp · Fresenius Kabi · Opioid agonist · Neuroscience
  Full mu-opioid receptor agonist providing analgesia through CNS opioid receptor activation.
• placebo then opana then darvocet · University of Rochester · Opioid analgesic · Pain Management
  This is a clinical trial comparing placebo to two opioid analgesics (oxymorphone and propoxyphene) for pain relief.
• Step 2 · Green Cross Corporation · Opioid antagonist · Psychiatry
  Step 2 is a medication used to treat opioid use disorder.
• OxyNEO® · Centre for Addiction and Mental Health · Opioid analgesic, abuse-deterrent formulation · Pain Management
  OxyNEO is an extended-release formulation of oxycodone designed to deter abuse by resisting crushing, dissolving, and extraction while maintaining analgesic efficacy.
• Placebo then darvocet then opana · University of Rochester · Opioid analgesic · Pain Management
  This is a clinical trial sequence comparing placebo against two opioid analgesics (Darvocet and Opana) for pain relief.
• Piritramid (analgetic) · Technische Universität Dresden · Opioid analgesic · Pain Management
  Piritramid is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia.
• Post-operative · Pontificia Universidad Catolica de Chile · Opioid · Pain management
  This drug works by inhibiting the action of certain neurotransmitters in the brain.
• Preoperative Methadone · University of Louisville · Opioid agonist · Anesthesia/Perioperative Medicine
  Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to provide analgesia and sedation for preoperative use.
• Hydromorphone HCl OROS · Janssen Korea, Ltd., Korea · Opioid agonist · Pain Management
  Hydromorphone HCl OROS is an opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and is formulated as an extended-release osmotic system for sustained pain relief.
• Darvocet then placebo then opana · University of Rochester · Opioid analgesic · Pain Management
  This is a study comparing three opioid pain medications: Darvocet (propoxyphene/acetaminophen), placebo, and Opana (oxymorphone), to evaluate their relative efficacy and safety in pain management.
• MEPERIDINE · opioid analgesic · Metabolic
  Meperidine is an opioid agonist that binds to mu-opioid receptors to produce analgesia and sedation.
• dextropropoxyphene hydrochloride · University Hospitals Bristol and Weston NHS Foundation Trust · Opioid analgesic · Pain management
  Dextropropoxyphene is an opioid analgesic that binds to mu opioid receptors in the central nervous system to reduce pain perception.
• opana then placebo then darvocet · University of Rochester · Opioid analgesic (mu-opioid receptor agonist) · Pain Management
  This is a study comparing the pain-relief efficacy and safety of oxymorphone (Opana) versus placebo and propoxyphene/acetaminophen (Darvocet) in patients with chronic pain.

Phase 3 pipeline (31)

• Counseling + Methadone · Friends Research Institute, Inc. · Opioid agonist (with behavioral intervention) · Addiction Medicine / Substance Use Disorder
  Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system, while counseling provides behavioral and psychosocial support to address substance use disorder.
• Pharmacologic Pain Management · University of California, San Francisco · Opioid · Pain Management
  This drug modulates the activity of the mu-opioid receptor to reduce pain perception.
• morphine IV PCA · Talphera, Inc · opioid · Pain management
  Morphine binds to opioid receptors in the brain and spinal cord, producing analgesia and altering mood.
• Morphine Sulfate Sustained-Release Tablet · Mundipharma (China) Pharmaceutical Co. Ltd · Opioid · Pain Management
  Morphine sulfate works by binding to opioid receptors in the brain and spinal cord, producing analgesia and altering emotional responses to pain.
• Oxycodone DETERx · Collegium Pharmaceutical, Inc. · Opioid analgesic (abuse-deterrent formulation) · Pain Management
  Oxycodone DETERx is an extended-release formulation of oxycodone, a mu-opioid receptor agonist, designed with abuse-deterrent technology to reduce the potential for misuse.
• Opioid stable treatment · Rigshospitalet, Denmark · Opioid agonist maintenance therapy · Addiction Medicine / Substance Use Disorder
  Opioid stable treatment maintains consistent opioid dosing to prevent withdrawal and reduce illicit drug use in opioid-dependent patients.
• pre-implementation baseline including opioid · Brigham and Women's Hospital · Opioid partial agonist · Addiction
  Buprenorphine is a partial opioid agonist that works by activating opioid receptors in the brain, reducing the craving for opioids and alleviating withdrawal symptoms.
• Tramadol HCl/Acetaminophen IR · Janssen Korea, Ltd., Korea · Opioid agonist and non-opioid analgesic combination · Pain management
  Tramadol HCl/Acetaminophen IR is a combination of a centrally acting opioid analgesic and a non-opioid analgesic that works by affecting the central nervous system to relieve pain.
• oPLB · National Institute on Drug Abuse (NIDA) · Partial mu-opioid receptor agonist · Psychiatry / Addiction Medicine
  oPLB is a long-acting buprenorphine formulation designed to provide sustained opioid agonist therapy for opioid use disorder.
• Tramadol Once A Day · Labopharm Inc. · Opioid analgesic · Pain management
  Tramadol is a centrally acting opioid analgesic that works by binding to opioid receptors in the brain and spinal cord.
• Oxycodone & naloxone combination, prolonged release · Mundipharma Research GmbH & Co KG · opioid agonist-antagonist · Pain management
  Oxycodone is a mu-opioid receptor agonist, while naloxone is a mu-opioid receptor antagonist.
• SC Methylnaltrexone · Bausch Health Americas, Inc. · opioid antagonist · Gastrointestinal
  SC Methylnaltrexone is a peripherally acting mu-opioid receptor antagonist that blocks the action of opioids in the gastrointestinal tract.
• Neonatal Morphine Solution · Tufts Medical Center · Opioid · Pain Management
  Morphine is a potent opioid agonist that binds to opioid receptors in the brain and spinal cord, producing analgesia and sedation.
• nebulized morphine · University of Monastir · opioid · Pain management
  Nebulized morphine works by releasing morphine into the lungs to provide pain relief.
• treatment withdrawal · University Hospital, Strasbourg, France · opioid antagonist · Psychiatry
  Withdrawal treatment involves the use of medications to help manage withdrawal symptoms in individuals who are dependent on substances such as opioids, alcohol, or benzodiazepines.
• OROS hydromorphone HCL ; Morphine sulfate · Alza Corporation, DE, USA · Opioid analgesic · Pain Management
  OROS hydromorphone HCl is an extended-release opioid agonist that binds to mu opioid receptors in the central nervous system to provide prolonged pain relief.
• methadone tablets · University of Sao Paulo · opioid · Pain management
  Methadone tablets work by activating the mu-opioid receptor in the brain, which helps to reduce withdrawal symptoms and alleviate pain.
• Meperidine Injection · Centre hospitalier de l'Université de Montréal (CHUM) · Opioid analgesic · Pain Management
  Meperidine is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.
• Tramadol HCl Contramid® Once A Day · Labopharm Inc. · Opioid analgesic · Pain management
  Tramadol HCl is a centrally acting opioid analgesic that works by binding to mu-opioid receptors in the brain.
• Tramadol HCl Twice a day · Labopharm Inc. · Opioid analgesic · Pain management
  Tramadol HCl is a centrally acting opioid analgesic that works by binding to opioid receptors in the brain and spinal cord, reducing pain perception.
• Hydromorphone, liquid oral · University of British Columbia · Opioid analgesic · Pain Management
  Hydromorphone is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation.
• Oxycodone and naloxone · Mundipharma Pharmaceuticals B.V. · opioid · Pain
  Oxycodone is a mu-opioid receptor agonist, while naloxone is a mu-opioid receptor antagonist.
• Hydrocodone ER · Teva Branded Pharmaceutical Products R&D, Inc. · Opioid analgesic · Pain Management
  Hydrocodone is an opioid agonist that binds to mu-opioid receptors in the central nervous system to reduce pain perception and provide analgesia.
• Methadone Treatment-As-Usual · Friends Research Institute, Inc. · opioid agonist · Addiction
  Methadone is a mu-opioid receptor agonist that works by activating opioid receptors in the brain, reducing withdrawal symptoms and cravings in individuals with opioid use disorder.
• single dose Morphine · Norwegian University of Science and Technology · opioid · Pain
  Morphine acts as a mu-opioid receptor agonist, producing analgesia by activating these receptors in the brain and spinal cord.
• Sufentanyl/Levobupivacaine · Brugmann University Hospital · Opioid agonist and local anesthetic · Anesthesiology
  Sufentanyl/Levobupivacaine is a combination of a potent opioid analgesic and a local anesthetic.
• Standard Buprenorphine Dose · Rutgers, The State University of New Jersey · Opioid partial agonist · Pain management
  Buprenorphine acts as a partial agonist at the mu-opioid receptor, providing pain relief and reducing withdrawal symptoms.
• morphine, amethocaine · The Hospital for Sick Children · opioid · Pain management
  Morphine is a potent opioid agonist that binds to opioid receptors in the brain, spinal cord, and other areas to produce analgesia and euphoria.
• Sufentanil + Lidocaïne · University Hospital, Montpellier · Opioid analgesic · Pain management
  Sufentanil is a potent opioid analgesic that acts as a mu-opioid receptor agonist, while Lidocaïne is a local anesthetic that blocks sodium channels.
• double dose Morphine · Norwegian University of Science and Technology · opioid · Pain management
  Morphine acts as a mu-opioid receptor agonist, producing analgesia by activating these receptors in the brain and spinal cord.
• PBO-N/PBO-B · Alkermes, Inc. · partial opioid agonist · Pain
  PBO-N/PBO-B is a partial opioid agonist.

Phase 2 pipeline (2)

• Chlorhydrate de morphine · Assistance Publique - Hôpitaux de Paris · opioid · Pain management
  Chlorhydrate de morphine is a potent opioid analgesic that acts as a mu-opioid receptor agonist.
• Daily Methadone Dose · Cari Health Inc. · opioid · Neurology
  opioid receptor agonist

Phase 1 pipeline (1)

• Actiq® 400 µg transmucosally · INSYS Therapeutics Inc · opioid analgesic · Pain Management
  Fentanyl acts by binding to opioid receptors, primarily mu-opioid receptors, in the central nervous system to produce analgesia and euphoria.