What are Opioid Antagonist drugs?

Opioid Antagonist drugs are pharmacologic agents that share a common mechanism (typically targeting Mu-type opioid receptor). 13 are currently marketed, with 5 more in clinical development.

What are the marketed Opioid Antagonist drugs?

Marketed Opioid Antagonist drugs include Relistor, Revex, Symproic, Movantik, Narcan, Vivitrol (Medication Therapy).

Opioid Antagonist

13 marketed 5 in Phase 3

This page covers all Opioid Antagonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Mu-type opioid receptor, Kappa-type opioid receptor, Opioid receptors (mu, delta, kappa).

Targets

Mu-type opioid receptor · Kappa-type opioid receptor · Opioid receptors (mu, delta, kappa) · µ-opioid receptor · opioid receptor · Mu opioid receptor · opioid receptors · mu-opioid receptor

Marketed (13)

Relistor · Salix Pharms · Pain · 400
Relistor works by blocking opioid receptors in the gut to alleviate constipation.
Revex · Hikma · Neuroscience · 400
Symproic · Bdsi · Metabolic
Symproic works by blocking the mu-type opioid receptor, which is responsible for slowing down bowel movements.
Movantik · Averitas · Oncology
Movantik works by blocking the mu-type opioid receptor, which is responsible for the constipating effects of opioids.
Narcan · Adapt · Neuroscience
Vivitrol (Medication Therapy) · Pacific Institute for Research and Evaluation · Psychiatry / Addiction Medicine
Vivitrol is a long-acting opioid antagonist that blocks opioid receptors to prevent euphoria and reduce cravings in opioid and alcohol use disorders.
Entereg · Cubist Pharms · Pain
Alvimopan selectively antagonizes µ-opioid receptors in the gastrointestinal tract, improving motility without affecting central analgesia.
nasal naloxone · Norwegian University of Science and Technology · Emergency medicine / Toxicology
Naloxone is an opioid antagonist that blocks opioid receptors to rapidly reverse opioid overdose effects.
over dose · Nanfang Hospital, Southern Medical University · Emergency Medicine
Naloxone works by binding to opioid receptors in the brain, reversing the effects of opioid overdose.
Naloxone infusion · Middle Tennessee Research Institute · Emergency Medicine / Toxicology
Naloxone is an opioid antagonist that blocks opioid receptors to reverse opioid overdose and respiratory depression.
Oral Naltrexone (O-NTX) · NYU Langone Health · Psychiatry / Addiction Medicine
Oral naltrexone is an opioid receptor antagonist that blocks opioid signaling in the central and peripheral nervous system.
Naloxone Hydrochloride Injection, USP · Pfizer · Emergency Medicine / Toxicology
Naloxone competitively blocks opioid receptors to rapidly reverse opioid overdose and restore normal breathing.
Step 2 · Green Cross Corporation · Psychiatry
Step 2 is a medication used to treat opioid use disorder.

Phase 3 pipeline (5)

Naloxone, intramuscular · Norwegian University of Science and Technology · Emergency Medicine / Toxicology
Naloxone is an opioid antagonist that blocks opioid receptors to rapidly reverse opioid overdose and restore normal breathing.
Naloxone HCl PR tablets · Develco Pharma Schweiz AG · Addiction Medicine / Emergency Medicine
Naloxone HCl is a competitive opioid receptor antagonist that blocks the effects of opioids by binding to opioid receptors without activating them.
Naloxone, intranasal · Norwegian University of Science and Technology · Emergency Medicine
Naloxone reverses opioid overdose by competitively binding to opioid receptors.
SC Methylnaltrexone · Bausch Health Americas, Inc. · Gastrointestinal
SC Methylnaltrexone is a peripherally acting mu-opioid receptor antagonist that blocks the action of opioids in the gastrointestinal tract.
treatment withdrawal · University Hospital, Strasbourg, France · Psychiatry
Withdrawal treatment involves the use of medications to help manage withdrawal symptoms in individuals who are dependent on substances such as opioids, alcohol, or benzodiazepines.