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nasal naloxone

Norwegian University of Science and Technology · FDA-approved active Small molecule

nasal naloxone is a Opioid antagonist Small molecule drug developed by Norwegian University of Science and Technology. It is currently FDA-approved for Opioid overdose reversal, Emergency treatment of known or suspected opioid overdose.

Naloxone is an opioid antagonist that blocks opioid receptors to rapidly reverse opioid overdose effects.

Naloxone is an opioid antagonist that blocks opioid receptors to rapidly reverse opioid overdose effects. Used for Opioid overdose reversal, Emergency treatment of known or suspected opioid overdose.

At a glance

Generic namenasal naloxone
SponsorNorwegian University of Science and Technology
Drug classOpioid antagonist
TargetOpioid receptors (mu, delta, kappa)
ModalitySmall molecule
Therapeutic areaEmergency medicine / Toxicology
PhaseFDA-approved

Mechanism of action

Naloxone competitively binds to opioid receptors (mu, delta, and kappa) with higher affinity than opioids, displacing opioids from these receptors and reversing respiratory depression, sedation, and other opioid effects. The nasal formulation allows rapid intranasal absorption for quick onset of action in emergency overdose situations. This is particularly valuable for opioid overdose reversal in community and out-of-hospital settings.

Approved indications

Common side effects

Key clinical trials

Primary sources

Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.

SourceUsed for
ClinicalTrials.govTrial enrolment, design, endpoints, results

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Frequently asked questions about nasal naloxone

What is nasal naloxone?

nasal naloxone is a Opioid antagonist drug developed by Norwegian University of Science and Technology, indicated for Opioid overdose reversal, Emergency treatment of known or suspected opioid overdose.

How does nasal naloxone work?

Naloxone is an opioid antagonist that blocks opioid receptors to rapidly reverse opioid overdose effects.

What is nasal naloxone used for?

nasal naloxone is indicated for Opioid overdose reversal, Emergency treatment of known or suspected opioid overdose.

Who makes nasal naloxone?

nasal naloxone is developed and marketed by Norwegian University of Science and Technology (see full Norwegian University of Science and Technology pipeline at /company/norwegian-university-of-science-and-technology).

What drug class is nasal naloxone in?

nasal naloxone belongs to the Opioid antagonist class. See all Opioid antagonist drugs at /class/opioid-antagonist.

What development phase is nasal naloxone in?

nasal naloxone is FDA-approved (marketed).

What are the side effects of nasal naloxone?

Common side effects of nasal naloxone include Acute withdrawal syndrome (in opioid-dependent patients), Nasal irritation, Headache, Tachycardia.

What does nasal naloxone target?

nasal naloxone targets Opioid receptors (mu, delta, kappa) and is a Opioid antagonist.

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