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morphine IV PCA
Morphine binds to opioid receptors in the brain and spinal cord, producing analgesia and altering mood.
Morphine binds to opioid receptors in the brain and spinal cord, producing analgesia and altering mood. Used for Severe pain, Cancer pain.
At a glance
| Generic name | morphine IV PCA |
|---|---|
| Sponsor | Talphera, Inc |
| Drug class | opioid |
| Target | mu-opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Pain management |
| Phase | Phase 3 |
Mechanism of action
Morphine is a mu-opioid receptor agonist, which means it activates these receptors to produce its effects. This activation leads to the inhibition of pain transmission in the spinal cord and the release of neurotransmitters that produce feelings of euphoria and relaxation.
Approved indications
- Severe pain
- Cancer pain
Common side effects
- Nausea
- Vomiting
- Constipation
- Dizziness
- Somnolence
Key clinical trials
- Examining Analgesic Synergy and Efficacy in Trauma Care (PHASE4)
- Comparing the Safety and Effectiveness of Different Doses of Morphine Administered in Spinal Anethesia for Pain Relief After Hip Replacement Surgery (PHASE4)
- Intrathecal Morphine for Recovery and Outcomes After VATS (NA)
- Spinal Anesthesia For Enhanced Recovery After Liver Surgery (NA)
- Comparison of BiFeS + ACB and IPACK + ACB Block Combinations for Postoperative Pain After Total Knee Arthroplasty
- Analgesic Efficacy of Multiple Mid-Transverse Process to Pleura (MTP) Block and PCA in Idiopathic Scoliosis Patients Undergoing Posterior Spinal Fusion (NA)
- External Oblique Intercostal Block in Laparoscopic Cholecystectomy (NA)
- Effect of Bilateral Rectointercostal Fascial Plane Block on Postoperative Pain After Laparoscopic Sleeve Gastrectomy (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |