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Split dose of methadone
Split-dose methadone divides the daily methadone dose into multiple administrations to optimize plasma levels and reduce peak-trough fluctuations.
Split-dose methadone divides the daily methadone dose into multiple administrations to optimize plasma levels and reduce peak-trough fluctuations. Used for Opioid use disorder maintenance treatment, Chronic pain management.
At a glance
| Generic name | Split dose of methadone |
|---|---|
| Sponsor | Wake Forest University Health Sciences |
| Drug class | Opioid agonist |
| Target | Mu opioid receptor |
| Modality | Small molecule |
| Therapeutic area | Addiction Medicine / Pain Management |
| Phase | FDA-approved |
Mechanism of action
Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system. By administering methadone in split doses rather than a single daily dose, the regimen aims to maintain more stable opioid receptor occupancy throughout the day, potentially reducing withdrawal symptoms and cravings while minimizing side effects associated with high peak concentrations.
Approved indications
- Opioid use disorder maintenance treatment
- Chronic pain management
Common side effects
- Constipation
- Sedation
- Respiratory depression
- Nausea
- Sweating
- Dizziness
Key clinical trials
- Methadone Pharmacokinetics in Cardiac Surgery (PHASE4)
- Divided or Single Exposure (DOSE) Study (PHASE2, PHASE3)
- Fostering MAT Use in Justice Populations (NA)
Primary sources
Every claim on this page is sourced from regulatory or scientific primary sources. See our editorial policy for full methodology.
| Source | Used for |
|---|---|
| ClinicalTrials.gov | Trial enrolment, design, endpoints, results |
Competitive intelligence
For the full competitive landscape — auto-detected comparators, recent regulatory actions across the set, upcoming PDUFA, patent timeline, sponsor landscape:
- Split dose of methadone CI brief — competitive landscape report
- Split dose of methadone updates RSS · CI watch RSS
- Wake Forest University Health Sciences portfolio CI