Opioid Agonist
This page covers all Opioid Agonist drugs tracked by Drug Landscape: marketed products and active clinical-stage compounds, targeting Mu-type opioid receptor, Mu (μ) opioid receptor, Mu opioid receptor (OPRM1).
Targets
Mu-type opioid receptor · Mu (μ) opioid receptor · Mu opioid receptor (OPRM1) · Mu-opioid receptor (μ-OR) · mu-opioid receptor · Mu-opioid receptor (OPRM1) · Mu opioid receptor · Mu-opioid receptor · Mu opioid receptor (primary), delta opioid receptor, kappa opioid receptor · Glutamate receptor ionotropic, NMDA 3A
Marketed (51)
- Opana Er · Endo · Neuroscience
- Alfenta · Rising · Pain
- Duramorph Pf · Pfizer · Neuroscience
Duramorph Pf works by binding to opioid receptors in the brain and spinal cord, mimicking the natural pain-relieving chemicals in the body. - Preservative Free Morphine · Icahn School of Medicine at Mount Sinai · Pain Management
Morphine is an opioid agonist that binds to mu opioid receptors in the central and peripheral nervous system to produce analgesia and other opioid effects. - Dilaudid Injectable Product · University of California, Davis · Pain Management
Dilaudid (hydromorphone) is an opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation. - Diamorphine or Morphine · London North West Healthcare NHS Trust · Pain management
Diamorphine and morphine are opioid agonists that bind to mu opioid receptors in the central and peripheral nervous system to reduce pain perception and produce analgesia. - Sufentanil epidural bolus · University of Genova · Pain management, Anesthesia
Sufentanil is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central and peripheral nervous system to produce analgesia and sedation. - Initial remifentanil effect-site concentration · Tri-Service General Hospital · Anesthesia and Analgesia
Remifentanil is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce rapid analgesia and sedation. - Fada Remifentanilo · Fundación Universitaria de Ciencias de la Salud · Anesthesia and Pain Management
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - Tussionex Pennkinetic · Teva · Neuroscience
Tussionex Pennkinetic works by binding to opioid receptors in the brain, which helps to reduce pain and congestion. - Propoxyphene Compound 65 · Pain
- Dilaudid-Hp · Fresenius Kabi · Neuroscience
Hydromorphone binds primarily to mu-opioid receptors, producing analgesia without a ceiling effect. - Levo-Dromoran · Bausch Health · Neuroscience
Levorphanol binds primarily to mu-opioid receptors to produce analgesia, with no ceiling effect for pain relief. - Low dose of alfentanil hydrochloride · University Hospital, Ghent · Anesthesia/Analgesia
Alfentanil hydrochloride is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. - intra-nasal fentanyl · Genesys · Pain Management
Intra-nasal fentanyl is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to rapidly produce analgesia and sedation. - Remifentanyl, Ultiva® · Fundación Universitaria de Ciencias de la Salud · Anesthesia
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - Preoperative Methadone · University of Louisville · Anesthesia/Perioperative Medicine
Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to provide analgesia and sedation for preoperative use. - Hydromorphone HCl OROS · Janssen Korea, Ltd., Korea · Pain Management
Hydromorphone HCl OROS is an opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and is formulated as an extended-release osmotic system for sustained pain relief. - Remifentanil fixed · Erasme University Hospital · Anesthesia / Analgesia
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - remifentanil injected · University Hospital, Ghent · Anesthesia and Analgesia
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - Sublingual Sufentanil · University of Minnesota · Pain Management
Sublingual sufentanil is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to produce rapid analgesia. - Sufentanil Bolus · University of Nebraska · Pain Management, Anesthesia
Sufentanil is a potent opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and sedation. - Sufenta Preservative Free · Rising · Pain
Sufentanil works by binding to opioid receptors in the brain, spinal cord, and other areas to produce pain relief. - general anesthesia (fentanyl) · Rambam Health Care Campus · Anesthesia
Fentanyl is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. - Intrathecal Morphine/Sufentanil · Université de Sherbrooke · Pain Management
Intrathecal morphine and sufentanil are opioid agonists that bind to opioid receptors in the spinal cord to block pain signal transmission. - Remifentanil adapted to SPI · Erasme University Hospital · Anesthesia / Perioperative Pain Management
Remifentanil is a potent opioid agonist that binds to mu-opioid receptors to provide rapid-onset, short-acting analgesia and sedation, with dosing adapted to Surgical Pleth Index (SPI) for real-time pain monitoring. - Alfentanil Hydrochloride Injection · The First Affiliated Hospital of Xinxiang Medical College · Anesthesia and Pain Management
Alfentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - Fentanyl Opioid anesthesia · University of Alexandria · Anesthesia
Fentanyl binds to opioid receptors in the central nervous system to produce anesthesia, analgesia, and sedation. - Diluted Deodorized Tincture of Opium · Eastern Maine Medical Center · Pain management, Gastroenterology
Diluted Deodorized Tincture of Opium (DDO) is an opioid preparation that binds to opioid receptors in the central and peripheral nervous system to produce analgesia and antidiarrheal effects. - Sufentanil 5 microgram/ml · Rigshospitalet, Denmark · Anesthesia and Pain Management
Sufentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce analgesia and sedation. - Propoxyphene Compound 65 · Pain
- Meperidine Hydrochloride Preservative Free · Pfizer · Pain
Meperidine Hydrochloride Preservative Free works by binding to opioid receptors in the brain, altering the perception of and response to pain. - Fentanyl - PICU Standard · Vanderbilt University Medical Center · Anesthesia/Critical Care
Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. - Continuous remifentanil Infusion · Kaohsiung Veterans General Hospital. · Anesthesia and Analgesia
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - fentanyl 15 microg · Corporacion Parc Tauli · Pain Management
Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. - Morphine and oxycodone · Ullevaal University Hospital · Pain management
Morphine and oxycodone are opioid agonists that bind to mu opioid receptors in the central nervous system to reduce pain perception and provide analgesia. - Methadone Hydrochloride · Specgx Llc · Neuroscience
Methadone is a synthetic opioid that acts as a mu-agonist, providing analgesia and aiding in opioid addiction management. - Remifentanil 2 µg/kg · Rigshospitalet, Denmark · Anesthesia and Analgesia
Remifentanil is a potent synthetic opioid agonist that binds to mu (μ) opioid receptors in the central nervous system to produce rapid analgesia and sedation. - Fentanyl (F1) · Oslo University Hospital · Pain management, Anesthesia
Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. - Intravenous Fentanyl guided by SoC+NOL · Ciusss de L'Est de l'Île de Montréal · Anesthesia and Pain Management
Intravenous fentanyl is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation, with dosing guided by real-time monitoring of the nociceptive level (NOL index) combined with standard of care (SoC) assessment.
Phase 3 pipeline (17)
- Opioid Anesthetics · Kasr El Aini Hospital · Anesthesiology
Opioid anesthetics bind to opioid receptors in the central nervous system to produce analgesia, sedation, and unconsciousness for surgical procedures. - Fentanyl (Matrifen) · Nycomed · Pain Management
Fentanyl is a synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. - Diacetylmorphine, liquid oral · University of British Columbia · Pain management / Opioid use disorder
Diacetylmorphine (heroin) is an opioid agonist that binds to mu, delta, and kappa opioid receptors in the central nervous system to produce analgesia, euphoria, and sedation. - Opioid administration morphine · KK Women's and Children's Hospital · Pain management
Morphine binds to opioid receptors in the central and peripheral nervous system to reduce pain perception and modulate emotional responses to pain. - Fentanyl intranasal · University Children's Hospital, Zurich · Pain management, Anesthesia
Fentanyl is a potent synthetic opioid agonist that binds to mu-opioid receptors in the central nervous system to produce analgesia and sedation. - Parenteral /oral methadone ratio 1:1.2 · L'Hospitalet de Llobregat · Pain management; Substance use disorder
Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system to produce analgesia and suppress withdrawal symptoms. - OraVescent fentanyl (OVF) · Cephalon · Pain Management
OraVescent fentanyl is a rapid-onset opioid agonist delivered via an effervescent oral formulation that enhances buccal absorption of fentanyl for fast pain relief. - Diamorphine hydrochloride · University of British Columbia · Pain Management, Addiction Medicine
Diamorphine hydrochloride is an opioid agonist that binds to mu, delta, and kappa opioid receptors in the central and peripheral nervous system to produce analgesia and euphoria. - IV opioid · Montefiore Medical Center · Pain Management
IV opioids bind to opioid receptors in the central and peripheral nervous system to reduce pain perception and provide analgesia. - Methadone Treatment-As-Usual · Friends Research Institute, Inc. · Addiction
Methadone is a mu-opioid receptor agonist that works by activating opioid receptors in the brain, reducing withdrawal symptoms and cravings in individuals with opioid use disorder. - ORAVESCENT Fentanyl Citrate · Cephalon · Pain Management
Fentanyl citrate binds to opioid receptors in the central nervous system to produce analgesia and sedation. - Morphine Titration · University of Monastir · Pain Management
Morphine is an opioid agonist that binds to mu opioid receptors in the central and peripheral nervous system to produce analgesia and other opioid effects. - IN fentanyl · Assistance Publique - Hôpitaux de Paris · Pain Management
Intranasal fentanyl is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to provide rapid pain relief. - Opioid Anesthesia · University Hospital, Grenoble · Anesthesia
Opioid anesthesia works by binding to opioid receptors in the central nervous system to produce analgesia and sedation for surgical procedures. - Nasal fentanyl · Nycomed · Pain Management
Nasal fentanyl is a potent opioid agonist that binds to mu-opioid receptors in the central nervous system to provide rapid pain relief through intranasal delivery. - Diacetylmorphine, injectable · University of British Columbia · Pain management / Addiction medicine
Diacetylmorphine (heroin) is a mu-opioid receptor agonist that binds to opioid receptors in the central nervous system to produce analgesia and euphoria. - Nebulized Fentanyl · Hamad Medical Corporation · Pain Management, Anesthesia
Nebulized fentanyl is an inhaled opioid agonist that binds to mu opioid receptors in the central nervous system to provide rapid analgesia and sedation.
Phase 2 pipeline (1)
- Morphine Dinicotinate · Pain
NICOMORPHINE works by binding to opioid receptors in the brain, producing feelings of pain relief and potentially other effects.